Browsing by Author "Melgar, Silvia"

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Browsing by Author "Melgar, Silvia"

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  • Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis 
    Murphy, Carola T.; Moloney, Gerard; Hall, Lindsay J.; Quinlan, Aoife; Faivre, Emilie; Casey, Pat G.; Shanahan, Fergus; Melgar, Silvia; Nally, Kenneth (Blackwell Publishing Ltd., 2010-10)
    Inflammatory bowel disease (IBD) is associated with neutrophil infiltration into the mucosa and crypt abscesses. The chemokine interleukin (IL)-8 [murine homologues (KC) and macrophage inflammatory protein (MIP)-2] and its ...
  • Shining a light on intestinal traffic 
    Murphy, Carola T.; Nally, Kenneth; Shanahan, Fergus; Melgar, Silvia (Hindawi Publishing Corporation, 2012-01)
    Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. ...
  • The spingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium 
    Murphy, Carola T.; Hall, Lindsay J.; Hurley, Grainne; Quinlan, Aoife; MacSharry, John; Shanahan, Fergus; Nally, Kenneth; Melgar, Silvia (American Society for Microbiology, 2012-08)
    The sphingosine-1-phosphate (S1P) analogue, FTY720, is therapeutically efficacious in multiple sclerosis and in the prevention of transplant rejection. It prevents migration of lymphocytes to sites of pathology by trapping ...