Human intestinal microbiota and metabolites they produce in relation to host health
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Date
2014
Authors
Russell, David A.
Journal Title
Journal ISSN
Volume Title
Publisher
University College Cork
Published Version
Abstract
The aim of this thesis was to identify selected potential probiotic characteristics of Bifidobacterium longum strains isolated from human sources, and to examine these characteristics in detail using genomic and phenotypic techniques. One strain in particular Bifidobacterium longum DPC 6315 was the main focus of the thesis and this strain was used in both the manufacture of yoghurt and an animal study. In total, 38 B. longum strains, obtained from infants and adults, were assessed in vitro for the selected probiotic traits using a combined phenotypic and molecular approach. Differentiation of the 38 strains using amplified ribosomal DNA restriction analysis (ARDRA) into subspecies indicated that of the 38 bifidobacterial strains tested, 34 were designated B. longum subsp. longum and four B. longum subsp. infantis.
Description
Keywords
Bifidobacteria , Probiotic , Metabolic activities , Human health , Food applications
Citation
Russell, D. A. 2014. Human intestinal microbiota and metabolites they produce in relation to host health. PhD Thesis, University College Cork.