Dennison, Una; McKernan, Declan P.; Cryan, John F.; Dinan, Timothy G.(Cambridge University Press, 2012)
Background. Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with
this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory ...
Guo, Jianfeng; Fisher, Karen A.; Darcy, Raphael; Cryan, John F.; O'Driscoll, Caitríona M.(Royal Society of Chemistry, 2010-04)
Gene silencing using RNA-interference, first described in mammalian systems almost a decade ago, is revolutionizing therapeutic target validation efforts both in vitro and in vivo. Moreover, the potential for using short ...
Callaerts-Vegh, Zsuzsanna; Beckers, Tom; Ball, Simon M.; Baeyens, Frank; Callaerts, Patrick F.; Cryan, John F.; Molnar, Elek; D’Hooge, Rudi(Society for Neuroscience, 2006-06)
Metabotropic glutamate receptor 7 (mGluR7), a receptor with a distinct brain distribution and a putative role in anxiety, emotional responding, and spatial working memory, could be an interesting therapeutic target for ...
Miller, Anne-Marie; Deighan, Brian F.; Downer, Eric; Lyons, Anthony; Henric-Noak, Petra; Nolan, Yvonne M.; Lynch, Marina A.(InTech, 2011-12)
Neuroinflammation, accompanied by neuronal loss and dysfunction, is a characteristic of
neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD). It
is well documented that inappropriate ...
O'Mahony, Aoife M.; Doyle, D.; Darcy, Raphael; Cryan, John F.; O'Driscoll, Caitríona M.(Elsevier, 2012-12-18)
Significant research is focused on the development of non-viral vectors for delivery of siRNA to neurons and the central nervous system. Cyclodextrins (CDs) have shown great promise as efficient and low toxicity gene ...