Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract

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Date
2008-10
Authors
Watson, Debbie
Sleator, Roy D.
Hill, Colin
Gahan, Cormac G.
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Publisher
BioMed Central
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Research Projects
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Abstract
The majority of commensal gastrointestinal bacteria used as probiotics are highly adapted to the specialised environment of the large bowel. However, unlike pathogenic bacteria; they are often inadequately equipped to endure the physicochemical stresses of gastrointestinal (GI) delivery in the host. Herein we outline a patho-biotechnology strategy to improve gastric delivery and host adaptation of a probiotic strain Bifidobacterium breve UCC2003 and the generally regarded as safe (GRAS) organism Lactococcus lactis NZ9000.
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Keywords
Gastrointestinal bacteria , Lactococcus lactis , Gastrointestinal delivery , Bile tolerance
Citation
Watson D, Sleator RD, Hill C, Gahan CG; (2008) 'Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract'. BMC Microbiology, 8:176. doi: 10.1186/1471-2180-8-176