Comparison of fenofibrate-mesoporous silica drug-loading processes for enhanced drug delivery

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dc.contributor.authorAhern, Robert J.
dc.contributor.authorHanrahan, John P.
dc.contributor.authorTobin, Joseph M.
dc.contributor.authorRyan, Katie B.
dc.contributor.authorCrean, Abina M.
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2023-12-14T15:11:13Z
dc.date.available2023-12-07T20:17:41Zen
dc.date.available2023-12-14T15:11:13Z
dc.date.issued2013-08-24
dc.date.updated2023-12-07T20:17:44Zen
dc.description.abstractLoading a poorly water-soluble drug onto a high surface area carrier such as mesoporous silica (SBA-15) can increase the drug's dissolution rate and oral bioavailability. The loading method can influence subsequent drug properties including solid state structure and release rate. The objective of this research was to compare several loading processes in terms of drug distribution throughout the mesoporous silica matrix, drug solid state form and drug release properties. A model poorly water-soluble drug fenabrate was loaded onto SBA-15 using; (i) physical mixing, (ii) melt, (iii) solvent impregnation, (iv) liquid CO2 and (v) supercritical CO2 methods. Physical mixing resulted in heterogeneous drug-loading, with no evidence of drug in the mesopores and the retention of the drug in its crystalline state. The other loading processes yielded more homogeneous drug-loading; the drug was deposited into the mesopores of the SBA-15 and was non-crystalline. All the processing methods resulted in enhanced drug release compared to the unprocessed drug with the impregnation, liquid and SC-CO2 producing the greatest increase at t=30 min. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAhern, R.J., Hanrahan, J.P., Tobin, J.M., Ryan, K.B. and Crean, A.M. (2013) ‘Comparison of fenofibrate–mesoporous silica drug-loading processes for enhanced drug delivery’, European Journal of Pharmaceutical Sciences, 50(3–4), pp. 400–409. Available at: https://doi.org/10.1016/j.ejps.2013.08.026
dc.identifier.doi10.1016/j.ejps.2013.08.026en
dc.identifier.endpage409
dc.identifier.issn0928-0987
dc.identifier.issued3-4
dc.identifier.journaltitleEuropean Journal of Pharmaceutical Sciences
dc.identifier.startpage400
dc.identifier.urihttps://hdl.handle.net/10468/15320
dc.identifier.volume50
dc.language.isoenen
dc.publisherElsevier
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Strategic Research Cluster Programme/07/SRC/B1158/IE/SRC SSPS: Solid State Pharmaceuticals Cluster (SSPC)/
dc.relation.urihttps://doi.org/10.1016/j.ejps.2013.08.026
dc.rights© 2013 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSBA-15
dc.subjectFenofibrate
dc.subjectSupercritical CO2
dc.subjectPoorly water-soluble
dc.subjectAmorphous
dc.subjectDrug-loading
dc.titleComparison of fenofibrate-mesoporous silica drug-loading processes for enhanced drug deliveryen
dc.typeArticle (peer-reviewed)en
dc.typeArticleen
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