Regioselective partial hydrogenation and deuteration of tetracyclic (Hetero)aromatic systems using a simple heterogeneous catalyst

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dc.contributor.authorKehoe, Roberta A.en
dc.contributor.authorLowry, Amyen
dc.contributor.authorLight, Mark E.en
dc.contributor.authorJones, David J.en
dc.contributor.authorByrne, Peteren
dc.contributor.authorMcGlacken, Gerard P.en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2024-01-23T10:11:12Z
dc.date.available2024-01-23T10:11:12Z
dc.date.issued2024-11-12en
dc.description.abstractThe introduction of added ‘3-dimensionality’ through late-stage functionalization of extended (hetero)aromatic systems is a powerful synthetic approach. The abundance of starting materials and cross-coupling methodologies to access the precursors allows for highly diverse products. Subsequent selective partial reduction can alter the core structure in a manner of interest to medicinal chemists. Herein, we describe the precise, partial reduction of multicyclic heteroaromatic systems using a simple heterogeneous catalyst. The approach can be extended to introduce deuterium (again at late-stage). Excellent yields can be obtained using simple reaction conditions.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide202400102en
dc.identifier.citationKehoe, R.A., Lowry, A., Light, M.E., Jones, D.J., Byrne, P.A. and McGlacken, G.P. (2024) ‘Regioselective partial hydrogenation and deuteration of tetracyclic (Hetero)aromatic systems using a simple heterogeneous catalyst’, Chemistry – A European Journal, e202400102 (7 pp). Available at: https://doi.org/10.1002/chem.202400102.en
dc.identifier.doihttps://doi.org/10.1002/chem.202400102en
dc.identifier.endpage7en
dc.identifier.issn0947-6539en
dc.identifier.issn1521-3765en
dc.identifier.journaltitleChemistry – A European Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15414
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofChemistry – A European Journalen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IP/1315/IE/The Direct Arylation of Pyrones, Coumarins, Pyridones and Quinolones/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Frontiers for the Future::Award/21/FFP-A/8784/IE/SOSEarth: Sustainable Organic Synthesis using Earth Abundant Metals for Critical Pharmaceutical Transformations/en
dc.rights© 2024 The Authors. Open Access. Published by Wiley under a creative commons license: https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPharmaceutical drug designen
dc.subjectMedicinal chemists.en
dc.subject(Hetero)aromatic systemsen
dc.subjectMolecular editingen
dc.subject3-dimensionalityen
dc.subjectAcOD-d4en
dc.subjectDeuteriumen
dc.titleRegioselective partial hydrogenation and deuteration of tetracyclic (Hetero)aromatic systems using a simple heterogeneous catalysten
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
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