Associations between the nutrient profiling system underlying the nutri-score nutrition label and biomarkers of chronic low-grade inflammation: a cross-sectional analysis of a middle- to older-aged population
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Published Version
Supplementary Materials
Date
2022
Authors
Millar, Seán R.
Navarro, Pilar
Harrington, Janas M.
Perry, Ivan J.
Phillips, Catherine M.
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Published Version
Abstract
Low-grade systemic inflammation is associated with a range of conditions. Diet may modulate inflammation and public health strategies are needed to guide consumers' dietary choices and help prevent diet-related disease. The Food Standards Agency nutrient profiling system (FSAm-NPS) constitutes the basis of the five-colour front-of-pack Nutri-Score labelling system. No study to date has examined FSAm-NPS dietary index associations with biomarkers of inflammation. Therefore, our objective was to test relationships between the FSAm-NPS and a range of inflammatory biomarkers in a cross-sectional sample of 2006 men and women aged 46-73 years. Individual participant FSAm-NPS scores were derived from food frequency questionnaires. Pro-inflammatory cytokine, adipocytokine, acute-phase response protein, coagulation factor and white blood cell count concentrations were determined. Correlation and linear regression analyses were used to examine FSAm-NPS relationships with biomarker levels. In crude and adjusted analyses, higher FSAm-NPS scores, reflecting poorer nutritional quality, were consistently and positively associated with biomarkers. In fully adjusted models, significant associations with concentrations of complement component 3, c-reactive protein, interleukin 6, tumour necrosis factor alpha, resistin, white blood cell count, neutrophils, eosinophils and the neutrophil-to-lymphocyte ratio persisted. These results suggest that dietary quality, determined by Nutri-Score rating, is associated with inflammatory biomarkers related to health.
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Keywords
Nutri-score , Diet , Chronic , Inflammation , Biomarkers
Citation
Millar, S. R, Navarro, P., Harrington, J. M., Perry, I. J. and Phillips, C. M. (2022) 'Associations between the nutrient profiling system underlying the nutri-score nutrition label and biomarkers of chronic low-grade inflammation: a cross-sectional analysis of a middle- to older-aged population', Nutrients, 14 (15), (11 pp). doi: 10.3390/nu14153122