Development of a PPG-based hardware and software system deployable on elbow and thumb for real-time estimation of pulse transit time

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dc.contributor.authorValerio, Andreaen
dc.contributor.authorHajzeraj, Adhurimen
dc.contributor.authorTalebi, Omid Varnosfaderanien
dc.contributor.authorBelcastro, Marcoen
dc.contributor.authorTedesco, Salvatoreen
dc.contributor.authorDemarchi, Daniloen
dc.contributor.authorO'Flynn, Brendanen
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Regional Development Funden
dc.date.accessioned2024-03-13T15:19:12Z
dc.date.available2024-03-13T15:19:12Z
dc.date.issued2023-07-24en
dc.description.abstractBlood pressure (BP) is a vital parameter used by clinicians to diagnose issues in the human cardiovascular system. Cuff-based BP devices are currently the standard method for on-the-spot and ambulatory BP measurements. However, cuff-based devices are not comfortable and are not suitable for long-term BP monitoring. Many studies have reported a significant correlation between pulse transit time (PTT) with blood pressure. However, this relation is impacted by many internal and external factors which might lower the accuracy of the PTT method. In this paper, we present a novel hardware system consisting of two custom photoplethysmography (PPG) sensors designed particularly for the estimation of PTT. In addition, a software interface and algorithms have been implemented to perform a real-time assessment of the PTT and other features of interest from signals gathered between the brachial artery and the thumb. A preclinical study has been conducted to validate the system. Five healthy volunteer subjects were tested and the results were then compared with those gathered using a reference device. The analysis reports a mean difference among subjects equal to -3.75±7.28 ms. Moreover, the standard deviation values obtained for each individual showed comparable results with the reference device, proving to be a valuable tool to investigate the factors impacting the BP-PTT relationship.Clinical Relevance— The proposed system proved to be a feasible solution to detect blood volume changes providing good quality signals to be used in the study of BP-PTT relationship.en
dc.description.sponsorshipEnterprise Ireland (Disruptive Technologies Innovation Fund (DTIF) project HOLISTICS funded by Enterprise Ireland (EI))en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationValerio, A., Hajzeraj, A., Talebi, O.V., Belcastro, M., Tedesco, S., Demarchi, D. and O’Flynn, B. (2023) ‘Development of a PPG-based hardware and software system deployable on elbow and thumb for real-time estimation of pulse transit time’, in 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). Sydney, Australia, 24-27 July. Available at: https://doi.org/10.1109/EMBC40787.2023.10340784en
dc.identifier.doihttps://doi.org/10.1109/EMBC40787.2023.10340784en
dc.identifier.endpage5en
dc.identifier.isbn979-8-3503-2447-1en
dc.identifier.isbn979-8-3503-2448-8en
dc.identifier.issn2694-0604en
dc.identifier.issn2375-7477en
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15674
dc.language.isoenen
dc.publisherIEEEen
dc.relation.ispartof2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2289-P2s/IE/INSIGHT Phase 2/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 1/16/RC/3918/IE/Confirm Centre for Smart Manufacturing/en
dc.rights© 2023 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other worksen
dc.subjectPerformance evaluationen
dc.subjectEstimationen
dc.subjectThumben
dc.subjectReal-time systemsen
dc.subjectSensor systemsen
dc.subjectHardwareen
dc.subjectBlood pressureen
dc.subjectHumansen
dc.subjectElbowen
dc.subjectPhotoplethysmographyen
dc.subjectThumben
dc.subjectPulse Wave Analysisen
dc.subjectSoftwareen
dc.titleDevelopment of a PPG-based hardware and software system deployable on elbow and thumb for real-time estimation of pulse transit timeen
dc.typeArticle (peer-reviewed)en
dc.typeConference itemen
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