Understanding the p-toluenesulfonamide/triphenylphosphine oxide crystal chemistry: a new 1:1 cocrystal and ternary phase diagram

Simple item page
dc.contributor.authorCroker, Denise M.
dc.contributor.authorForeman, Michael E.
dc.contributor.authorHogan, Bridget N.
dc.contributor.authorMaguire, Nuala M.
dc.contributor.authorElcoate, Curtis J.
dc.contributor.authorHodnett, Benjamin K.
dc.contributor.authorMaguire, Anita R.
dc.contributor.authorRasmuson, Ake C.
dc.contributor.authorLawrence, Simon E.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2013-01-30T13:24:45Z
dc.date.available2013-01-30T13:24:45Z
dc.date.copyright2011
dc.date.issued2012
dc.date.updated2012-12-20T14:20:17Z
dc.description.abstractA novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state. The ternary phase diagram for the two coformers was constructed in two different solvents: acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system.en
dc.description.sponsorshipScience Foundation Ireland (07/SRC/B1158); Science Foundation Ireland (05/PICA/B802/EC07)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCroker, Denise M., Foreman, Michael E., Hogan, Bridget N., Maguire, Nuala M., Elcoate, Curtis J., Hodnett, Benjamin K., Maguire, Anita R., Rasmuson, Ake C., Lawrence, Simon E. (2012) 'Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram'. Crystal Growth & Design, 12 (2):869-875. http://pubs.acs.org/doi/abs/10.1021/cg201300een
dc.identifier.doi10.1021/cg201300e
dc.identifier.endpage875en
dc.identifier.issued2en
dc.identifier.journaltitleCrystal Growth & Designen
dc.identifier.startpage869en
dc.identifier.urihttps://hdl.handle.net/10468/949
dc.identifier.volume12en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttp://pubs.acs.org/doi/abs/10.1021/cg201300e
dc.rights© 2011, American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher.To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/cg201300een
dc.subjectCrystallographyen
dc.subjectLiquid crystalsen
dc.subjectCocrystalsen
dc.subject.lcshCrystallizationen
dc.titleUnderstanding the p-toluenesulfonamide/triphenylphosphine oxide crystal chemistry: a new 1:1 cocrystal and ternary phase diagramen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
DMC_understandingAV2012.pdf
Size:
814.54 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Chemistry - Journal Articles
Analytical & Biological Chemistry Research Facility - Journal Articles
Pharmacy - Journal Articles