Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract

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dc.contributor.authorWatson, Debbie
dc.contributor.authorSleator, Roy D.
dc.contributor.authorHill, Colin
dc.contributor.authorGahan, Cormac G.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2013-02-20T16:19:50Z
dc.date.available2013-02-20T16:19:50Z
dc.date.copyright2008
dc.date.issued2008-10
dc.date.updated2013-02-04T13:48:28Z
dc.description.abstractThe majority of commensal gastrointestinal bacteria used as probiotics are highly adapted to the specialised environment of the large bowel. However, unlike pathogenic bacteria; they are often inadequately equipped to endure the physicochemical stresses of gastrointestinal (GI) delivery in the host. Herein we outline a patho-biotechnology strategy to improve gastric delivery and host adaptation of a probiotic strain Bifidobacterium breve UCC2003 and the generally regarded as safe (GRAS) organism Lactococcus lactis NZ9000.en
dc.description.sponsorshipScience Foundation Ireland (05/RFP/Gen0021)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWatson D, Sleator RD, Hill C, Gahan CG; (2008) 'Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract'. BMC Microbiology, 8:176. doi: 10.1186/1471-2180-8-176en
dc.identifier.doi10.1186/1471-2180-8-176
dc.identifier.journaltitleBMC Microbiologyen
dc.identifier.urihttps://hdl.handle.net/10468/984
dc.identifier.volume8en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urihttp://www.biomedcentral.com/1471-2180/8/176
dc.rights© 2008 Watson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en
dc.subjectGastrointestinal bacteriaen
dc.subjectLactococcus lactisen
dc.subjectGastrointestinal deliveryen
dc.subjectBile toleranceen
dc.subject.lcshMicrobiologyen
dc.subject.lcshProbioticsen
dc.titleEnhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tracten
dc.typeArticle (peer-reviewed)en
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