Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes

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dc.contributor.authorVan de Velde, Sébastien
dc.contributor.authorCarryn, Stéphane
dc.contributor.authorVan Bambeke, Françoise
dc.contributor.authorHill, Colin
dc.contributor.authorTulkens, Paul M.
dc.contributor.authorSleator, Roy D.
dc.contributor.funderDirection Générale de la Recherche et des Technologies de la Région Wallonne, Belguimfr
dc.contributor.funderEumedica SA, Belgiumen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2012-11-09T08:32:08Z
dc.date.available2012-11-09T08:32:08Z
dc.date.copyright2009-12
dc.date.issued2009-12-15
dc.description.abstractWhile seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.en
dc.description.sponsorshipDirection Générale de la Recherche et des Technologies de la Région Wallonne, Belguim (FIRST-Doctorate Fellowship); Science Foundation Ireland (SFI-CSET)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationVan de Velde, S. and Carryn, S. and Van Bambeke, F. and Hill, C. and Tulkens, P.M. and Sleator, R.D. (2009) 'Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes'. Gut pathogens, 1:23 doi: 10.1186/1757-4749-1-23en
dc.identifier.doi10.1186/1757-4749-1-23
dc.identifier.issn1757-4749
dc.identifier.issued1en
dc.identifier.journaltitleGut Pathogensen
dc.identifier.startpage23en
dc.identifier.urihttps://hdl.handle.net/10468/751
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urihttp://www.gutpathogens.com/content/1/1/23
dc.rights© 2009 Van de Velde et al; licensee BioMed Central Ltd.en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en
dc.subjectPenicillinen
dc.subjectPenicillin-Bindingen
dc.subjectListeria monocytogenesen
dc.subjectCephalosporinen
dc.subjectCarbapenemen
dc.subjectRadiolabelleden
dc.titlePenicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenesen
dc.typeArticle (peer-reviewed)en
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