To investigate the effect of plasma rich in growth factors (PRGF) on healing and quality of life following mandibular third molar removal

Simple item page
dc.availability.bitstreamembargoed
dc.check.date2022-09-30
dc.contributor.advisorNi Riordain, Richealen
dc.contributor.authorO'Sullivan, Laura
dc.date.accessioned2021-09-23T09:06:28Z
dc.date.available2021-09-23T09:06:28Z
dc.date.issued2021
dc.date.submitted2021
dc.description.abstractObjectives: To investigate the effect of plasma rich in growth factors (PRGF) on clinician-reported and patient-reported outcomes following surgical removal of a unilateral impacted mandibular third molar. Materials and Methods: Ethical approval to conduct this prospective, double-blind randomised controlled trial (RCT) was granted by the local Clinical Research Ethics Committee. Seventy-four patients requiring surgical removal of a single impacted mandibular third molar (M3M) under local anaesthesia were recruited to participate. A blood sample was obtained immediately pre-operatively (T0) for all participants irrespective of study arm allocation, and PRGF prepared according to the product protocol. Patients allocated to the treatment arm received PRGF clot in the third molar socket after tooth removal. All patients received a telephone call 3 days postoperatively (T1), and were asked to return to the clinic for review 7 days postoperatively (T2). Primary outcome measures were NRS (numeric rating scale) pain score, OHIP-14 (Oral Health Impact Profile-14) and PoSSe (Postoperative Symptom Severity) scale data. Secondary outcome measures such as mouth opening (MIO), dry socket, socket healing and analgesia consumption were also explored. Statistical analysis was performed using IBM SPSS® 25.0 software and Stata® 15.1. ANCOVA was used for analysis of NRS, OHIP-14 and PoSSe total scores and MIO outcomes. Categorical variables were analysed using the Chi square test. Results: The mean age of participants was 28.1years (range 19-39, SD 5.8) with females accounting for 77% of the study population. NRS scores were higher in the PRGF group at T1 (4.1±2.4) demonstrating borderline significance (p=0.06) with no significant difference at T2. No significant differences were observed in PoSSe subscales between groups overall, with the exception of the ‘interference with daily activities’ subscale at T1, with PRGF patients scoring on average 1.2units higher (p=0.02). OHIP-14 outcomes revealed patients in the PRGF group were 25% more likely to experience discomfort on eating at T1 (p=0.02) with no significant difference between groups at T2. Reduced MIO was observed at T2 in control (35.7±8.2) and PRGF groups (35.4±8.5), but was not significant (p=0.67). The incidence of dry socket was not significant between groups (p=0.3). Socket healing, graded using a modified Landry et al healing index, did not vary significantly between groups: control 4.0±1.2, PRGF 3.6±1.2, nor did analgesia consumption. Conclusion: The results of this study did not demonstrate any significant difference in clinical or quality of life outcomes in patients following adjunctive use of PRGF in mandibular third molar sockets.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Sullivan, L. 2021. To investigate the effect of plasma rich in growth factors (PRGF) on healing and quality of life following mandibular third molar removal. PhD Thesis, University College Cork.en
dc.identifier.endpage225en
dc.identifier.urihttps://hdl.handle.net/10468/11986
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2021, Laura O'Sullivan.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectThird molaren
dc.subjectQuality of lifeen
dc.subjectPlasma rich in growth factorsen
dc.subjectWisdom teethen
dc.titleTo investigate the effect of plasma rich in growth factors (PRGF) on healing and quality of life following mandibular third molar removalen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameDClinDent - Doctor of Clinical Dentistryen
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
104050452 - Laura O'Sullivan.pdf
Size:
4.59 MB
Format:
Adobe Portable Document Format
Description:
Full Text E-thesis
Download
Thumbnail Image
Name:
3. 104050452-Laura O'Sullivan Submission Form.pdf
Size:
333.02 KB
Format:
Adobe Portable Document Format
Description:
Submission for Examination Form
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
5.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Theses Submission
College of Medicine and Health - Doctoral Theses
Cork University Dental School and Hospital - Doctoral Theses