Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease

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Date
2021
Authors
Stockdale, Stephen R.
Draper, Lorraine A.
O'Donovan, Sarah
Barton, Wiley
O'Sullivan, Orla
Volpicelli-Daley, Laura A.
Sullivan, Aideen M.
O'Neill, Cora
Hill, Colin
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Nature Research
Published Version
10.1038/s42003-021-02666-1
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Abstract
Parkinson’s disease (PD) is a chronic neurological disorder associated with the misfolding of alpha-synuclein (α-syn) into aggregates within nerve cells that contribute to their neurodegeneration. Recent evidence suggests α-syn aggregation may begin in the gut and travel to the brain along the vagus nerve, with microbes potentially a trigger initiating α-syn misfolding. However, the effects α-syn alterations on the gut virome have not been investigated. In this study, we show longitudinal faecal virome changes in rats administered either monomeric or preformed fibrils (PFF) of α-syn directly into their enteric nervous system. Differential changes in rat viromes were observed when comparing monomeric and PFF α-syn, with alterations compounded by the addition of LPS. Changes in rat faecal viromes were observed after one month and did not resolve within the study’s five-month observational period. These results suggest that virome alterations may be reactive to host α-syn changes that are associated with PD development.
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Keywords
Faecal viromes of rats , Alpha-synuclein , Parkinson’s disease
Citation
Stockdale, S.R., Draper, L.A., O’Donovan, S.M., Barton, W., O’Sullivan, O., Volpicelli-Daley, L.A., Sullivan, A.M., O’Neill, C. and Hill, C. (2021) ‘Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease’, Communications Biology, 4(1), 1140 (12pp). doi: 10.1038/s42003-021-02666-1
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https://hdl.handle.net/10468/15766
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APC Microbiome Ireland - Journal Articles
Anatomy and Neuroscience - Journal Articles
Biochemistry and Cell Biology - Journal Articles
Microbiology - Journal Articles
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© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.