%PDF-1.4
%
1 0 obj
<<
/Type /Catalog
/Version /1.4
/Pages 2 0 R
/PageLabels 3 0 R
/Metadata 4 0 R
/Names 5 0 R
/Outlines 6 0 R
/OutputIntents [7 0 R 8 0 R]
>>
endobj
9 0 obj
<<
/Creator (Apache FOP Version 2.2)
/Producer (Apache FOP Version 2.2)
/CreationDate (D:20240319062057Z)
/Title (Perceived barriers and facilitators to Risk Based Monitoring in academic-led clinical trials: a mixed methods study)
/Keywords (Risk-based monitoring,ICH-GCP,Monitoring)
/ModDate (D:20170911140746+02'00')
/Subject (Trials, 2017, doi:10.1186/s13063-017-2148-4)
/Author (Caroline Hurley)
>>
endobj
2 0 obj
<<
/Type /Pages
/Kids [10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R
20 0 R 21 0 R 22 0 R]
/Count 13
>>
endobj
3 0 obj
<<
/Nums [0 23 0 R]
>>
endobj
4 0 obj
<<
/Length 965
/Type /Metadata
/Subtype /XML
>>
stream
application/pdf
x-unknown
2024-03-19T06:20:57Z
Apache FOP Version 2.2
1.4
Apache FOP Version 2.2
2024-03-19T06:20:57Z
2024-03-19T06:20:57Z
endstream
endobj
5 0 obj
<<
/Dests 24 0 R
>>
endobj
6 0 obj
<<
/Type /Outlines
/Count 46
/Last 25 0 R
/First 26 0 R
>>
endobj
7 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 27 0 R
/S /GTS_PDFA1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
>>
endobj
8 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 27 0 R
/S /ISO_PDFE1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
>>
endobj
10 0 obj
<<
/Resources 28 0 R
/Type /Page
/MediaBox [0.0 0.0 595.275 841.889]
/CropBox [0.0 0.0 595.275 841.889]
/BleedBox [0 0 595.275 841.889]
/TrimBox [0 0 595.275 841.889]
/Parent 2 0 R
/Annots [29 0 R]
/Contents 30 0 R
/Rotate 0
>>
endobj
11 0 obj
<<
/Resources 28 0 R
/Type /Page
/MediaBox [0.0 0.0 595.275 841.889]
/CropBox [0.0 0.0 595.275 841.889]
/BleedBox [0 0 595.275 841.889]
/TrimBox [0 0 595.275 841.889]
/Parent 2 0 R
/Contents 31 0 R
/Rotate 0
>>
endobj
12 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents [32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R]
/Resources 40 0 R
/Thumb 41 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [42 0 R 43 0 R 44 0 R 45 0 R]
/Rotate 0
>>
endobj
13 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 46 0 R
/Resources 47 0 R
/Thumb 48 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R
59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R
69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R
79 0 R 80 0 R]
/Rotate 0
>>
endobj
14 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 81 0 R
/Resources 82 0 R
/Thumb 83 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R]
/Rotate 0
>>
endobj
15 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 91 0 R
/Resources 92 0 R
/Thumb 93 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R]
/Rotate 0
>>
endobj
16 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 103 0 R
/Resources 104 0 R
/Thumb 105 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R]
/Rotate 0
>>
endobj
17 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 112 0 R
/Resources 113 0 R
/Thumb 114 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [115 0 R 116 0 R 117 0 R 118 0 R]
/Rotate 0
>>
endobj
18 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 119 0 R
/Resources 120 0 R
/Thumb 121 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [122 0 R 123 0 R 124 0 R]
/Rotate 0
>>
endobj
19 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 125 0 R
/Resources 126 0 R
/Thumb 127 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R
138 0 R 139 0 R]
/Rotate 0
>>
endobj
20 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 140 0 R
/Resources 141 0 R
/Thumb 142 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R
153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R
163 0 R]
/Rotate 0
>>
endobj
21 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 164 0 R
/Resources 165 0 R
/Thumb 166 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R
177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R]
/Rotate 0
>>
endobj
22 0 obj
<<
/CropBox [0.0 0.0 595.276 790.866]
/Parent 2 0 R
/Type /Page
/Contents 187 0 R
/Resources 188 0 R
/Thumb 189 0 R
/MediaBox [0.0 0.0 595.276 790.866]
/Annots [190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R
200 0 R 201 0 R 202 0 R 203 0 R 204 0 R]
/Rotate 0
>>
endobj
23 0 obj
<<
/S /D
>>
endobj
24 0 obj
<<
/Kids [205 0 R 206 0 R 207 0 R]
>>
endobj
25 0 obj
<<
/C [0 0 0]
/Parent 6 0 R
/F 0
/Title
/Dest
/Prev 208 0 R
/Count 0
>>
endobj
26 0 obj
<<
/Next 209 0 R
/C [0 0 0]
/Parent 6 0 R
/F 0
/Title
/Dest
/Count 4
/Last 210 0 R
/First 211 0 R
>>
endobj
27 0 obj
<<
/Length 2574
/N 3
/Filter /FlateDecode
/Range [0 1 0 1 0 1]
>>
stream
HyTSwoɞc
[5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb
2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9
V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\
ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W=
x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. R
߁-25 S>ӣVd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L`< "AYA+Cb(R, *T2B-
ꇆnQt}MA0alSx k&^>0|>_',G!"F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VĭKĻYdE"EI2EBGt4MzNr!YK ?%_(0J:EAiQ(()ӔWT6U@P+!~mDeԴ!hӦh/']B/ҏӿ?a0nhF!X8܌kc&5S6lIa2cKMA!E#ƒdV(kel
}}Cq9
N')].uJr
wG xR^[oƜchg`>b$*~ :Eb~,m,-ݖ,Y¬*6X[ݱF=3뭷Y~dó tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:˜O:ϸ8uJqnv=MmR 4
n3ܣkGݯz=[==<=GTB(/S,]6*-W:#7*e^YDY}UjAyT`#D="b{ų+ʯ:!kJ4Gmt}uC%K7YVfFY.=b?SƕƩȺy
چk5%4m7lqlioZlG+Zzmzy]?uuw|"űNwW&e֥ﺱ*|j5kyݭǯg^ykEklD_p߶7Dmo꿻1ml{Mś
nLl<9O [$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD- u`ֲK³8%yhYѹJº;.!
zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs
2F[p(@Xr4Pm8Ww)Km
endstream
endobj
28 0 obj
<<
/Font 212 0 R
/ProcSet [/PDF /ImageB /ImageC /Text]
/XObject <<
/Im1 213 0 R
/Im2 214 0 R
/Im3 215 0 R
>>
/ColorSpace 216 0 R
>>
endobj
29 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [184.243 216.236 364.555 228.236]
/C [0 0 0]
/Border [0 0 0]
/A 217 0 R
/H /I
>>
endobj
30 0 obj
<<
/Length 2892
/Filter /FlateDecode
>>
stream
x]n6}v1`xٗ$jVO̸U*Ud&Ou!nN9̌8R]F7M{t7i^Q京(2]%v|Û̞sPP&3M^=~':[3J絬&Gݨ
??_N>ӯ__&
>jȟo!q+{AM^!F*BcMrdD.*2nͰZ9uV;aˌ^>ea+j_J2{}˾yve:Yͨ:#6G,Xu[}SOj[
VE'Hޯ]^=/~ׁszq2F[WSwO*MSy٨#*⣻Wym:єbOaÀR]Ʌ !siw#6pʗ+
)&,̤Q+VV])HSClkyu93E=+"0u03å^RfrfLtj{ko)
RdIsEW9=,4ѴXEx́Z?ڃeHAbW)Y GC"42!~5ڀ|r0H}8)7rA
##j:j,ZZמ>य़3Dx:7 #W6o:^PڄT:z6OnY4,B2':x}uaH ء`&/#jBp @cv]P34Lpvv2sV7|ޓ++8.1LXeHApo+Ftw0n,!7emH4j\Q&Z
5pyșDCBa̗2KSYk,8q&9ijU#!pW_bchO@hnpxO ̧c{M. T=-V_۽Gw_GvJnh4kH-T/
Kw-DlROnZP>*JKaa*-rj0{ߺn!m0{45e68M&.{pGC&^#J!EUa}ᘣKM=V;|T3"A]x_6Gފ=#stẵ,٤WWV_X۷9_CT} G
=Wy!+ԫjlP G+"`,kw cj
n^. 15$HC~8e 3mO p
.mpUg\DY5gtg״mswnivYdTmc2Ce` 5M yCX-?\q{n(+7{2z{FqPXkEk0ƅ(%ȩGߢо3Iں[QJ5W9C^aoB?3LcM[݆)w tk:+qb,ݨ4mۣejKW@~@lIVyBEBu3+=2taXb'אEMb#,܀/=3ġ)^