%PDF-1.4
%
1 0 obj
<<
/Type /Catalog
/Version /1.6
/Pages 2 0 R
/PageLabels 3 0 R
/Metadata 4 0 R
/AcroForm 5 0 R
/StructTreeRoot 6 0 R
/MarkInfo 7 0 R
/Lang (en-GB)
/ViewerPreferences 8 0 R
>>
endobj
9 0 obj
<<
/Creator (Apache FOP Version 2.2)
/Producer (Apache FOP Version 2.2)
/CreationDate (D:20240329131507Z)
/ModDate (D:20210226093424+01'00')
/Trapped /False
>>
endobj
2 0 obj
<<
/Type /Pages
/Kids [10 0 R 11 0 R 12 0 R]
/Count 3
>>
endobj
3 0 obj
<<
/Nums [0 13 0 R]
>>
endobj
4 0 obj
<<
/Length 965
/Type /Metadata
/Subtype /XML
>>
stream
application/pdf
x-unknown
2024-03-29T13:15:07Z
Apache FOP Version 2.2
1.4
Apache FOP Version 2.2
2024-03-29T13:15:07Z
2024-03-29T13:15:07Z
endstream
endobj
5 0 obj
<<
/DA (/Helv 0 Tf 0 g )
/DR 14 0 R
/Fields [15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R
25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R
35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R
45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
>>
endobj
6 0 obj
<<
/Type /StructTreeRoot
/ParentTree 53 0 R
/ParentTreeNextKey 3
/K [54 0 R]
/RoleMap 55 0 R
>>
endobj
7 0 obj
<<
/Marked true
/Suspects false
>>
endobj
8 0 obj
<<
/Direction /L2R
>>
endobj
10 0 obj
<<
/Resources 56 0 R
/Type /Page
/MediaBox [0.0 0.0 595.275 841.889]
/CropBox [0.0 0.0 595.275 841.889]
/BleedBox [0 0 595.275 841.889]
/TrimBox [0 0 595.275 841.889]
/Parent 2 0 R
/Annots [57 0 R]
/Contents 58 0 R
/Rotate 0
>>
endobj
11 0 obj
<<
/Annots [59 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R
24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 30 0 R 29 0 R 31 0 R 32 0 R 33 0 R
34 0 R 36 0 R 60 0 R 35 0 R]
/ArtBox [0 0 595.276 841.89]
/BleedBox [0 0 595.276 841.89]
/Contents [61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R]
/CropBox [0.0 0.0 595.276 841.89]
/LastModified (D:20201217134206Z)
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/PieceInfo 69 0 R
/Resources 70 0 R
/Rotate 0
/StructParents 0
/TrimBox [0 0 595.276 841.89]
/Type /Page
>>
endobj
12 0 obj
<<
/Annots [71 0 R 37 0 R 39 0 R 38 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R
47 0 R 46 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
/ArtBox [0 0 595.276 841.89]
/BleedBox [0 0 595.276 841.89]
/Contents 72 0 R
/CropBox [0.0 0.0 595.276 841.89]
/Group 73 0 R
/LastModified (D:20201217134206Z)
/MediaBox [0.0 0.0 595.276 841.89]
/Parent 2 0 R
/PieceInfo 74 0 R
/Resources 75 0 R
/Rotate 0
/StructParents 2
/TrimBox [0 0 595.276 841.89]
/Type /Page
>>
endobj
13 0 obj
<<
/S /D
>>
endobj
14 0 obj
<<
/Encoding 76 0 R
/Font 77 0 R
>>
endobj
15 0 obj
<<
/AP 78 0 R
/DA (/Helv 0 Tf 0 g)
/DR 79 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 617.72 558.36 650.4]
/Subtype /Widget
/T (Study design - 1a)
/TU (a. For each experiment, provide brief details of study design including: a. The groups being compared, including control groups. If no control group has been used, the rationale should be stated. )
/Type /Annot
/V <6129206D6574686F64730D>
>>
endobj
16 0 obj
<<
/AP 80 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 81 0 R
/P 11 0 R
/Rect [474.96 593.673 557.968 616.034]
/Subtype /Widget
/T (Study design - 1b)
/TU (b. The experimental unit \(e.g. a single animal, litter, or cage of animals\).)
/Type /Annot
/V (b\) fig. legends)
>>
endobj
17 0 obj
<<
/AP 82 0 R
/DA (/Helv 0 Tf 0 g)
/DR 83 0 R
/F 4
/FT /Tx
/Ff 4096
/MK 84 0 R
/P 11 0 R
/Rect [474.96 566.082 558.36 591]
/Subtype /Widget
/T (Sample size - 2a)
/TU (a. Specify the exact number of experimental units allocated to each group, and the total number in each experiment. Also indicate the total number of animals used.)
/Type /Annot
/V (a\) methods & fig.legends )
>>
endobj
18 0 obj
<<
/AP 85 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 86 0 R
/P 11 0 R
/Rect [474.96 540.378 558.36 564.931]
/Subtype /Widget
/T (Sample size - 2b)
/TU (b. Explain how the sample size was decided. Provide details of any a priori sample size calculation, if done.)
/Type /Annot
/V (b\) methods)
>>
endobj
19 0 obj
<<
/AP 87 0 R
/DA (/Helv 0 Tf 0 g)
/DR 88 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 511.725 558.36 537.12]
/Subtype /Widget
/T (Inclusion and exclusion criteria - 3a)
/TU (a. Describe any criteria used for including and excluding animals \(or experimental units\) during the experiment, and data points during the analysis. Specify if these criteria were established a priori. If no criteria were set, state this explicitly. )
/Type /Annot
/V (a\) methods)
>>
endobj
20 0 obj
<<
/AP 89 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 90 0 R
/P 11 0 R
/Rect [474.96 486.788 558.36 510.355]
/Subtype /Widget
/T (Inclusion and exclusion criteria - 3b)
/TU (b. For each experimental group, report any animals, experimental units or data points not included in the analysis and explain why. If there were no exclusions, state so.)
/Type /Annot
/V (b\) fig. legends)
>>
endobj
21 0 obj
<<
/AP 91 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 92 0 R
/P 11 0 R
/Rect [474.96 461.652 558.36 485.22]
/Subtype /Widget
/T (Inclusion and exclusion criteria - 3c)
/TU (c. For each analysis, report the exact value of n in each experimental group.)
/Type /Annot
/V (c\) fig. legends)
>>
endobj
22 0 obj
<<
/AP 93 0 R
/DA (/Helv 0 Tf 0 g)
/DR 94 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 423.543 558.36 458.28]
/Subtype /Widget
/T (Randomisation - 4a)
/TU (a. State whether randomisation was used to allocate experimental units to control and treatment groups. If done, provide the method used to generate the randomisation sequence. )
/Type /Annot
/V (a\) methods)
>>
endobj
23 0 obj
<<
/AP 95 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 96 0 R
/P 11 0 R
/Rect [474.96 388.567 558.36 421.843]
/Subtype /Widget
/T (Randomisation - 4b)
/TU (b. Describe the strategy used to minimise potential confounders such as the order of treatments and measurements, or animal/cage location. If confounders were not controlled, state this explicitly.)
/Type /Annot
/V (b\) N/A)
>>
endobj
24 0 obj
<<
/AP 97 0 R
/DA (/Helv 0 Tf 0 g)
/DR 98 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 349.124 558.36 385.08]
/Subtype /Widget
/T (Blinding - 5)
/TU (Describe who was aware of the group allocation at the different stages of the experiment \(during the allocation, the conduct of the experiment, the outcome assessment, and the data analysis\).)
/Type /Annot
/V (methods)
>>
endobj
25 0 obj
<<
/AP 99 0 R
/DA (/Helv 0 Tf 0 g)
/DR 100 0 R
/F 4
/FT /Tx
/Ff 4096
/MK 101 0 R
/P 11 0 R
/Rect [474.96 322.127 558.36 346.68]
/Subtype /Widget
/T (Outcome measures - 6a)
/TU (a. Clearly define all outcome measures assessed \(e.g. cell death, molecular markers, or behavioural changes\). )
/Type /Annot
/V (a\) methods)
>>
endobj
26 0 obj
<<
/AP 102 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 103 0 R
/P 11 0 R
/Rect [474.96 295.09 558.36 320.663]
/Subtype /Widget
/T (Outcome measures - 6b)
/TU (b. For hypothesis-testing studies, specify the primary outcome measure, i.e. the outcome measure that was used to determine the sample size.)
/Type /Annot
/V (b\) methods)
>>
endobj
27 0 obj
<<
/AP 104 0 R
/DA (/Helv 0 Tf 0 g)
/DR 105 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 267.636 558.36 292.8]
/Subtype /Widget
/T (Statistical methods - 7a)
/TU (a. Provide details of the statistical methods used for each analysis, including software used. )
/Type /Annot
/V (a\) methods & fig. legends)
>>
endobj
28 0 obj
<<
/AP 106 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 107 0 R
/P 11 0 R
/Rect [474.96 241.25 558.36 266.048]
/Subtype /Widget
/T (Statistical methods - 7b)
/TU (b. Describe any methods used to assess whether the data met the assumptions of the statistical approach, and what was done if the assumptions were not met.)
/Type /Annot
/V (b\) methods)
>>
endobj
29 0 obj
<<
/AP 108 0 R
/DA (/Helv 0 Tf 0 g)
/DR 109 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 213.709 558.36 239.04]
/Subtype /Widget
/T (Experimental animals - 8a)
/TU (a. Provide species-appropriate details of the animals used, including species, strain and substrain, sex, age or developmental stage, and, if relevant, weight. )
/Type /Annot
/V (a\) methods)
>>
endobj
30 0 obj
<<
/AP 110 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 111 0 R
/P 11 0 R
/Rect [474.96 187.934 558.36 212.741]
/Subtype /Widget
/T (Experimental animals - 8b)
/TU (b. Provide further relevant information on the provenance of animals, health/immune status, genetic modification status, genotype, and any previous procedures.)
/Type /Annot
/V (b\) methods)
>>
endobj
31 0 obj
<<
/AP 112 0 R
/DA (/Helv 0 Tf 0 g)
/DR 113 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 164.051 558.36 185.28]
/Subtype /Widget
/T (Experimental procedures - 9a)
/TU (For each experimental group, including controls, describe the procedures in enough detail to allow others to replicate them, including: a. What was done, how it was done and what was used. )
/Type /Annot
>>
endobj
32 0 obj
<<
/AP 114 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 115 0 R
/P 11 0 R
/Rect [474.96 141.719 558.36 162.949]
/Subtype /Widget
/T (Experimental procedures - 9b)
/TU (For each experimental group, including controls, describe the procedures in enough detail to allow others to replicate them, including: b. When and how often. )
/Type /Annot
/V (all in methods)
>>
endobj
33 0 obj
<<
/AP 116 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 117 0 R
/P 11 0 R
/Rect [474.96 119.552 558.36 140.454]
/Subtype /Widget
/T (Experimental procedures - 9c)
/TU (For each experimental group, including controls, describe the procedures in enough detail to allow others to replicate them, including: c. Where \(including detail of any acclimatisation periods\))
/Type /Annot
>>
endobj
34 0 obj
<<
/AP 118 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 119 0 R
/P 11 0 R
/Rect [474.96 96.894 558.36 118.45]
/Subtype /Widget
/T (Experimental procedures - 9d)
/TU (For each experimental group, including controls, describe the procedures in enough detail to allow others to replicate them, including: d. Why \(provide rationale for procedures\))
/Type /Annot
>>
endobj
35 0 obj
<<
/AP 120 0 R
/DA (/Helv 0 Tf 0 g)
/DR 121 0 R
/F 4
/FT /Tx
/Ff 4096
/P 11 0 R
/Rect [474.96 67.4182 558.36 94.7127]
/Subtype /Widget
/T (Results - 10a)
/TU (For each experiment conducted, including independent replications, report: a. Summary/descriptive statistics for each experimental group, with a measure of variability where applicable \(e.g. mean and SD, or median and range\). )
/Type /Annot
/V (a\) fig. legends)
>>
endobj
36 0 obj
<<
/AP 122 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 123 0 R
/P 11 0 R
/Rect [474.96 38.2723 558.36 66.0905]
/Subtype /Widget
/T (Results - 10b)
/TU (Results 10 For each experiment conducted, including independent replications, report: b. If applicable, the effect size with a confidence interval.)
/Type /Annot
/V (b\) N/A)
>>
endobj
37 0 obj
<<
/AP 124 0 R
/DA (/Helv 0 Tf 0 g)
/DR 125 0 R
/F 4
/FT /Tx
/P 12 0 R
/Rect [473.76 674.28 558.6 702.12]
/Subtype /Widget
/T (Abstract - 11)
/TU (Provide an accurate summary of the research objectives, animal species, strain and sex, key methods, principal findings, and study conclusions.)
/Type /Annot
/V (Abstract)
>>
endobj
38 0 obj
<<
/AP 126 0 R
/DA (/Helv 0 Tf 0 g)
/DR 127 0 R
/F 4
/FT /Tx
/Ff 4096
/P 12 0 R
/Rect [473.76 645.851 558.12 672.36]
/Subtype /Widget
/T (Background - 12a)
/TU (a. Include sufficient scientific background to understand the rationale and context for the study, and explain the experimental approach. )
/Type /Annot
/V (Introduction/Research in context)
>>
endobj
39 0 obj
<<
/AP 128 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 129 0 R
/P 12 0 R
/Rect [473.76 617.446 558.12 644.479]
/Subtype /Widget
/T (Background - 12b)
/TU (b. Explain how the animal species and model used address the scientific objectives and, where appropriate, the relevance to human biology.)
/Type /Annot
>>
endobj
40 0 obj
<<
/AP 130 0 R
/DA (/Helv 0 Tf 0 g)
/DR 131 0 R
/F 4
/FT /Tx
/P 12 0 R
/Rect [473.76 586.68 558.6 614.52]
/Subtype /Widget
/T (Objectives - 13)
/TU (Clearly describe the research question, research objectives and, where appropriate, specific hypotheses being tested.)
/Type /Annot
/V (Introduction-objectives outlined)
>>
endobj
41 0 obj
<<
/AP 132 0 R
/DA (/Helv 0 Tf 0 g)
/DR 133 0 R
/F 4
/FT /Tx
/Ff 4096
/P 12 0 R
/Rect [473.76 535.996 558.12 584.236]
/Subtype /Widget
/T (Ethical statement - 14)
/TU (Provide the name of the ethical review committee or equivalent that has approved the use of animals in this study, and any relevant licence or protocol numbers \(if applicable\). If ethical approval was not sought or granted, provide a justification.)
/Type /Annot
/V (Methods-ethics subsection)
>>
endobj
42 0 obj
<<
/AP 134 0 R
/DA (/Helv 0 Tf 0 g)
/DR 135 0 R
/F 4
/FT /Tx
/P 12 0 R
/Rect [473.76 504.84 558.6 532.68]
/Subtype /Widget
/T (Housing and husbandry - 15)
/TU (Provide details of housing and husbandry conditions, including any environmental enrichment.)
/Type /Annot
/V (Methods-animals)
>>
endobj
43 0 obj
<<
/AP 136 0 R
/DA (/Helv 0 Tf 0 g)
/DR 137 0 R
/F 4
/FT /Tx
/Ff 4096
/P 12 0 R
/Rect [473.76 475.385 558.12 503.247]
/Subtype /Widget
/T (Animal care and monitoring - 16a)
/TU (a. Describe any interventions or steps taken in the experimental protocols to reduce pain, suffering and distress.)
/Type /Annot
>>
endobj
44 0 obj
<<
/AP 138 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 139 0 R
/P 12 0 R
/Rect [473.76 446.85 558.12 474.712]
/Subtype /Widget
/T (Animal care and monitoring - 16b)
/TU (b. Report any expected or unexpected adverse events. )
/Type /Annot
/V (n/a)
>>
endobj
45 0 obj
<<
/AP 140 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 141 0 R
/P 12 0 R
/Rect [473.76 419.068 558.12 445.948]
/Subtype /Widget
/T (Animal care and monitoring - 16c)
/TU (c. Describe the humane endpoints established for the study, the signs that were monitored and the frequency of monitoring. If the study did not have humane endpoints, state this.)
/Type /Annot
/V (Methods-Animals-Weight monitoring)
>>
endobj
46 0 obj
<<
/AP 142 0 R
/DA (/Helv 0 Tf 0 g)
/DR 143 0 R
/F 4
/FT /Tx
/Ff 4096
/P 12 0 R
/Rect [473.76 389.804 558.12 416.52]
/Subtype /Widget
/T (Interpretation scientific implicationsm - 17a)
/TU (a. Interpret the results, taking into account the study objectives and hypotheses, current theory and other relevant studies in the literature.)
/Type /Annot
/V (Research in context/Discussion)
>>
endobj
47 0 obj
<<
/AP 144 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 145 0 R
/P 12 0 R
/Rect [473.76 361.416 558.12 388.656]
/Subtype /Widget
/T (Interpretation scientific implications - 17b)
/TU (b. Comment on the study limitations including potential sources of bias, limitations of the animal model, and imprecision associated with the results.)
/Type /Annot
/V (Discussion pg18)
>>
endobj
48 0 obj
<<
/AP 146 0 R
/DA (/Helv 0 Tf 0 g)
/DR 147 0 R
/F 4
/FT /Tx
/Ff 4096
/P 12 0 R
/Rect [473.76 319.56 558.12 358.56]
/Subtype /Widget
/T (Generalisability/translation - 18)
/TU (Comment on whether, and how, the findings of this study are likely to generalise to other species or experimental conditions, including any relevance to human biology \(where appropriate\).)
/Type /Annot
>>
endobj
49 0 obj
<<
/AP 148 0 R
/DA (/Helv 0 Tf 0 g)
/DR 149 0 R
/F 4
/FT /Tx
/Ff 4096
/P 12 0 R
/Rect [473.76 278.64 558.12 317.64]
/Subtype /Widget
/T (Protocol registration - 19)
/TU (Provide a statement indicating whether a protocol \(including the research question, key design features, and analysis plan\) was prepared before the study, and if and where this protocol was registered.)
/Type /Annot
/V (n/a)
>>
endobj
50 0 obj
<<
/AP 150 0 R
/DA (/Helv 0 Tf 0 g)
/DR 151 0 R
/F 4
/FT /Tx
/P 12 0 R
/Rect [473.76 248.52 558.6 277.32]
/Subtype /Widget
/T (Data access - 20)
/TU (Provide a statement describing if and where study data are available.)
/Type /Annot
/V (n/a)
>>
endobj
51 0 obj
<<
/AP 152 0 R
/DA (/Helv 0 Tf 0 g)
/DR 153 0 R
/F 4
/FT /Tx
/Ff 4096
/P 12 0 R
/Rect [473.76 219.687 558.12 246.6]
/Subtype /Widget
/T (Declaration of interests - 21a)
/TU (a. Declare any potential conflicts of interest, including financial and non-financial. If none exist, this should be stated. )
/Type /Annot
/V (End of manuscript pg 20 & completed COI forms)
>>
endobj
52 0 obj
<<
/AP 154 0 R
/DA (/Helv 0 Tf 0 g)
/F 4
/FT /Tx
/Ff 4096
/MK 155 0 R
/P 12 0 R
/Rect [473.76 191.725 558.12 218.638]
/Subtype /Widget
/T (Declaration of interests - 21b)
/TU (b. List all funding sources \(including grant identifier\) and the role of the funder\(s\) in the design, analysis and reporting of the study.)
/Type /Annot
/V (Methods, End of manuscript pg 20 & completed COI forms)
>>
endobj
53 0 obj
<<
/Limits [0 2]
/Nums [0 [156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R
166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R
176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R
186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R
196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R
206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R
216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R
226 0 R 227 0 R 228 0 R 229 0 R 230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R
236 0 R 237 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R
246 0 R 247 0 R 248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R
256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R]
1 265 0 R 2 [null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null null
null null null null null null null null null 266 0 R
267 0 R 268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R
277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R
287 0 R 288 0 R 289 0 R 290 0 R 291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R
297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R
307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R
317 0 R 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R
327 0 R 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R
337 0 R 338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R
347 0 R 348 0 R]
]
>>
endobj
54 0 obj
<<
/K 349 0 R
/Lang (en-GB)
/P 6 0 R
/S /Document
>>
endobj
55 0 obj
<<
/Article /Art
/NormalParagraphStyle /P
/Paragraph_Style_2 /P
/Paragraph_Style_2_co /P
/Story /Sect
/_No_paragraph_style_ /P
/subheads /P
>>
endobj
56 0 obj
<<
/Font 350 0 R
/ProcSet [/PDF /ImageB /ImageC /Text]
/XObject <<
/Im1 351 0 R
/Im2 352 0 R
/Im3 353 0 R
>>
/ColorSpace 354 0 R
>>
endobj
57 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [184.243 288.236 370.819 300.236]
/C [0 0 0]
/Border [0 0 0]
/A 355 0 R
/H /I
>>
endobj
58 0 obj
<<
/Length 2574
/Filter /FlateDecode
>>
stream
x]n6)Wb$Nh{E[.~IJ)8#g =ѐ3qfH;Vk[|~|onIuUji=Rjkkw*eeSJw^y5iR ]h[Lk?k~~
yZp!˚qHc[i-^6}φ?o>~rw|qԺo6kSW4cLV;!tP[iV2=㎋d%0Z8=Gb]ݑ)]aVyxIBRb/Żg(^m|>7N3L#@%jG- j; ħ ;}JNќDxߣ)U!Lr,&=Y=/ھ#σD*ᜢWǗil::-ѨDILKɅ<ЄӦDqll'Wޣ&26Z
51u
4UVVO#*3I3 7+MuF#O'J3~h/Zdٶdx8}4v2ph@UN͐dMU˺f
QxCI+uY0Kc,"3;L{BkTGuTGԥrnҚЊ{DŽ~oK9rFxʂS)8z'R&0'@LT91(&_r6@~*uȞSU*}4U:t~!*\<c