INFANT A research centre focused entirely on pregnancy, birth and early childhood. Hosted at University College Cork (UCC), Cork, Ireland, The Irish Centre for Maternal and Child Health Research has local impact with a global reach. INFANT is answering the international need for research and innovation to improve health outcomes for mothers and babies. Across pregnancy, birth, infancy and childhood, INFANT is solving challenges through its key research themes
(Springer Nature Limited, 2020-11-03) Marx, Wolfgang; Lane, Melissa; Hockey, Meghan; Aslam, Hajara; Berk, Michael; Walder, Ken; Borsini, Alessandra; Firth, Joseph; Pariante, Carmine M.; Berding, Kirsten; Cryan, John F.; Clarke, Gerard; Craig, Jeffrey M.; Su, Kuan-Pin; Mischoulon, David; Gomez-Pinilla, Fernando; Foster, Jane A; Cani, Patrice D.; Thuret, Sandrine; Staudacher, Heidi M.; Sánchez-Villegas, Almudena; Arshad, Husnain; Akbaraly, Tasnime; O'Neil, Adrienne; Segasby, Toby; Jacka, Felice N.; Deakin University; Multiple Sclerosis Research Australia; Australian Rotary Health; National Health and Medical Research Council; Medical Research Council; Horizon 2020; National Institute for Health Research; Irish Research Council; Science Foundation Ireland; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Health Research Board; Institute for Scientific Information on Coffee, UK; Saks Kavanaugh Foundation, United States; University of Manchester; UK Research and Innovation; Australian Research Council; Waterloo Foundation; DNA Genotek; Trajan Scientific and Medical, Australia; Ministry of Science and Technology, Taiwan; National Health Research Institutes; Universidade de Macau; Ministry of Education; China Medical University, Taiwan; China Medical University Hospital; Nordic Naturals, United States; National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Ontario Brain Institute; Fonds Baillet Latour; Fonds De La Recherche Scientifique - FNRS; European Research Council; Centre Hospitalier Régional Universitaire de Montpellier; National Heart Foundation of Australia; Wilson Foundation
The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.