Medicine - Conference Items
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- ItemNon-invasive multimodal spectroscopic diagnosis for early-stage oral cancer(Optica Publishing Group, 2023) Maryam, Siddra; Ghauri, Daniyal; Sekar, Sanathana Konugolu Venkata; Fahy, Edward; Saito Nogueira, Marcelo; Lu , Huihui; Beffara, Flavien; Humbert, Georges; Burke, Ray; Feeley, Linda; Sheahan, Patrick; Ni Riordain, Richeal; Andersson-Engels, Stefan; Wei Kho, Kiang; Gautam, Rekha; 2023This study aims to develop a multimodal scheme for diagnosing oral cancer non-invasively in its early stages and to assess the performance of an integrated diagnostic platform comprising of Raman and diffuse reflectance spectroscopy systems.
- ItemMulti-configuration Raman spectrometer for early stage diagnosis of oral cancer(Society of Photo-Optical Instrumentation Engineers (SPIE), 2022-03-02) Maryam, Siddra; Saito Nogueira, Marcelo; Krishna Moorthy, Shree; Sekar, Sanathana Konugolu Venkata ; Lu, Huihui; Gautam, Rekha; Burke, Ray; Andersson-Engels, Stefan; Ni Riordain, Richeal; Sheahan, Patrick; Huang, Zhiwei; Science Foundation IrelandOral Squamous Cell carcinoma (OSCC) is one of the most common and aggressive oral malignancies. Despite all significant advances in medicine, five-year survival rate is still 40%-60%. Diagnosis in early stages is critical as it can improve the survival rate and the quality of life after treatment. This study aims to develop a strategy for diagnosing oral cancer non-invasively in the early stages and to provide better surgical guidance by differentiating healthy and tumor tissues by using Raman spectroscopy. For this purpose, a multimodal Raman system is developed to detect oral cancer biomarkers in patient’s saliva specimen and to study different tissue types in oral cavity with Raman spectroscopy. The developed system is quite compact, easy to use and portable. It can be easily modified for in vivo and ex vivo analysis and can work in both reflection and transmission mode in case of ex vivo measurements. This paper compares the surface enhancement and background spectra from different plasmonic nanoparticles. Lastly, bovine serum albumin (BSA) and uric acid were used as model analytes to at physiologically relevant concentrations to test the performance of the system.
- ItemWorld Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: The patient perspective(Elsevier Inc., 2023-03-01) Diniz-Freitas, Márcio; López-Pintor, Rosa María; Bissonnette, Caroline; Dan, Hongxia; Kuduva Ramesh, Shilpa Shree; Valdéz, J. Amadeo; Brennan, Michael T.; Burkhart, Nancy W.; Farag, Arwa; Greenberg, Martin S.; Hong, Catherine; Setterfield, Jane F.; Woo, Sook-Bin; Sollecito, Thomas P.; Byrne, Harriet; Robledo-Sierra, Jairo; Taylor, Jennifer; Ni Riordain, RichealObjective: This study aimed to explore the lived experience of patients with oral lichen planus (OLP) and investigate what treatment-related outcomes are the most important to them and should be included in a core outcome set (COS) for OLP. Study Design: A qualitative study involving focus group work with 10 participants was conducted. Interviews with each focus group were held twice: session 1 explored the lived experience of patients with OLP, and session 2 allowed patients to review a summary of the outcome domains used in the OLP literature to date. The discussions were recorded, transcribed verbatim, and analyzed using framework analysis. Results: In session 1, 4 themes and 8 sub-themes emerged from the data analysis. An additional outcome, ‘knowledge of family and friends,’ was suggested in session 2. Conclusions: We have gained valuable insight into the lived experience of patients with OLP via this qualitative study. To our knowledge, this study is the first to explore the patient perspective on what should be measured in clinical trials on OLP, highlighting an important additional suggested outcome. This additional outcome will be voted upon in a consensus process to determine a minimum COS for OLP.
- ItemOpen source airway navigation: initial experiences with CustusX and Anser EMT(International Society for Medical Innovation and Technology (iSMIT), 2017) Jaeger, Herman A.; Trauzettel, Fabian; Hofstad, Erlend Fagertun; Kennedy, Marcus P.; Leira, Håkon; Langø, Thomas; Cantillon-Murphy, PádraigElectromagnetic tracking (EMT) is a common navigation technology used in image guided applications. EMT is particularly useful in procedures where line-of-sight of the operating field is not feasible. We present a major update of the open source electromagnetic tracking platform Anser EMT  and present its results when performing bronchoscopy in a pre-clinical setting using the CustusX navigation suite . The updated system design is open source and free to use and modify under the Berkeley Standard Distribution (BSD) license.
- ItemMechanical catheter navigation with electromagnetic tracking to peripheral airway targets(International Society for Medical Innovation and Technology (iSMIT), 2017) Trauzettel, Fabian; Jaeger, Herman A.; Hofstad, Erlend Fagertun; Kennedy, Marcus P.; Leira, Håkon; Langø, Thomas; Cantillon-Murphy, PádraigLung cancer remains the single most deadly cancer in men and women due to low rates of early detection and treatment. Since non-small cell lung cancer usually starts in the outer airways, targeted minimally invasive biopsy which limits radiation exposure and avoids surgery is highly desirable. Current commercial solutions such as the superDimension (Medtronic Inc., Dublin, Ireland), and SpIN (Veran Medical, St. Louis, USA) systems rely on electromagnetic tracking for virtual navigation. However, clinical outcomes have been unconvincing due to poor accuracy, limitations in instrumentation and the lack of tracked catheters. This work proposes a novel mechanical catheter design with embedded electromagnetic tracking to facilitate tip-tracked navigation without the need for proprietary instruments or probe exchange. The catheter was used to reach peripheral airway targets by multiple users in pre-clinical studies.