Pharmacy - Journal Articles
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Item Akkermansia muciniphila in infectious disease: A new target for this next-generation probiotic?(SAGE Publishing, 2024-03-15) Keane, Jonathan M.; Cazzaniga, Monica; Gahan, Cormac G. M.; Science Foundation Ireland; Horizon 2020The common gastrointestinal commensal Akkermansia muciniphila is a mucin-degrading bacterium that is greatly reduced in individuals consuming a high-fat diet. Increasing evidence from a variety of clinical and pre-clinical studies suggests that oral supplementation with Akkermansia can improve metabolic health and moderate systemic inflammation. We and others have demonstrated a role for Akkermansia administration in protection against infectious disease and the outcome from sepsis. Very recent studies have indicated the molecular mechanisms by which A. muciniphila may interact with the host to influence systemic immune-regulation and control of microbial pathogenesis. Here we consider recent studies which demonstrate the efficacy of this potential next-generation probiotic in animal models of Salmonella Typhimurium, Listeria monocytogenes and Clostridioides difficile as well as influenza virus and phlebovirus. The potential mechanisms by which A. muciniphila may influence local and systemic immune responses are discussed.Item The future of pharmaceutics: Showcasing emerging leaders in drug delivery(ACS Publications, 2024-12-02) Yen, Chun-Wan; O’Dwyer, Patrick; Wei, Weijun; Austin, Lauren A.; Feeney, Orlagh M.Item Factors influencing the healthcare programme selection of students in an Irish university(Elsevier Inc., 2024-12-26) Murphy, Roisin L.; Murphy, Kevin D.Background: Globally, there is a rapidly increasing proportion of women studying and practising healthcare. This has been accompanied by a reducing proportion of males in most healthcare professions. This has been a contributory factor to the decreasing health staffing due to the tendency of females to work fewer hours and leave their profession earlier. Considering the current shortage of healthcare workers, it is of utmost importance to determine the factors generating these choices, so that recruitment of a significant number of males is not missed. The main objective of this study was to ascertain differences between factors that influence men and women who are students in one Irish university. Methods: Semi-structured interviews were conducted with postgraduate and undergraduate Pharmacy, Nursing, Medicine, and Dentistry students. The interviews were then transcribed and a thematic analysis was applied to identify patterns and interrelationships in the data. Participants answered questions pertaining to the factors which influenced them to study healthcare. Results: Fourteen students participated in recorded interviews, with 8 of them being women. The interviews lasted between 12 and 27 min (mean: 18 min). Four themes were identified: (1) student characteristics, (2) content interest needs, (3) perceived career characteristics, and (4) external encouragement. This study confirmed that there is a social perception of some healthcare professions as a women's profession. The factors that influence men and women to study healthcare differed in some ways; females were more drawn to careers by which they could use empathy, while males were more interested by career prospects. Conclusions: This study offers insight into the decisions of students about their choice of healthcare profession. The study highlights factors that can be targeted by institutions wishing to increase the proportion of men or women in their professions. Using channels such as social media, school visits, and promotion of role models to demonstrate the variety of positions within each profession in terms of work-life balance, salary, career opportunity.Item Exploring the crystal landscape of mandelamide and chiral resolution via cocrystallization(American Chemical Society, 2025) Huang, Shan; Fitzgerald, Deirbhile; Koledoye, Samuel A.; Collins, Stuart G.; Maguire, Anita R.; Lawrence, Simon E.; Science Foundation Ireland; Irish Research CouncilThe crystal structures of (±)-mandelamide, S-mandelamide, and enantioenriched mandelamide (94 S : 6 R) were determined. Diastereomeric cocrystal pairs of S-mandelamide with both enantiomers of mandelic acid and proline were synthesized. The diastereomeric cocrystal pairs of S-mandelamide with S/R-mandelic acid form 1:1 cocrystals in each case, while the diastereomeric cocrystal pairs of S-mandelamide with proline have different stoichiometries. Preliminary investigation of this diastereomeric cocrystal system for chiral resolution shows promise.Item Exploring career choices of pharmacy graduates over 15 years: A cross-sectional evaluation(Elsevier Inc., 2024) Fitzpatrick, Katie L.; Allen, Evin A.; Griffin, Brendan T.; O'Shea, Joseph P.; Dalton, Kieran; Bennett-Lenane, HarrietIntroduction: Career opportunities for pharmacists beyond those commonly associated with the degree continue to emerge. A paucity of literature regarding evaluation of pharmacy graduate career paths over extended periods is apparent. Considering international pharmacy workforce capacity pressures, the primary study aim was to evaluate trends in career paths of pharmacy graduates. Methods: This study utilised a multimethod approach to access graduate career data using publicly accessible information from LinkedIn® profiles and an online survey. The survey was distributed to all pharmacy graduates of a university (2007–2022). Data from both methods was combined, cross-checked, coded and analysed quantitatively using descriptive and inferential statistics. Results: Data from 69.7% of the university's pharmacy graduates was collected. Community pharmacy was the most prevalent employment sector (47.7%), followed by industry (21.5%) and hospital (17.7%). A higher proportion of more recent graduates (≤5 years post-graduation) work in a community or hospital pharmacy role versus those who graduated greater than five years ago (χ2 = 8.44, df = 2, p < 0.05). Post-graduate education was undertaken by 41.3% of graduates. Career satisfaction was high (88.2%) but was lower (χ2 = 11.31, df = 1, p < 0.05) for those in community and hospital (82%) versus other sectors (97.5%). Conclusion: This study provides the first analysis of graduate career paths over an extended period, highlighting a novel approach to track pharmacist workforce. While almost two thirds of pharmacy graduates occupy community or hospital roles, a trend of leaving these settings five years post-graduation was evident. Accordingly, this work represents a springboard for additional research to inform future pharmacist workforce planning worldwide. © 2024 The Authors
