INFANT Research Centre - Journal Articles

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    Crying wolf: A qualitative review of misinformation and conspiracy theories in lupus erythematosus
    (SAGE Publishing, 2023-05-12) Porter, Emma; Murphy, Michelle; O’Connor, Cathal
    Background: Lupus comprises a complex group of inflammatory disorders including cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). The issue of health misinformation is increasingly problematic, although the content of misinformation related to lupus available online has not been deeply explored. This study aimed to qualitatively assess the type of misinformation related to lupus available online. Methods: A literature search on PubMed was conducted, using search terms “cutaneous lupus” OR “discoid lupus” OR “lupus” AND “misinformation” OR “conspiracy” OR “disinformation.” Further searches were also performed on Google, YouTube, Twitter, Facebook, Instagram, and TikTok. Results: Published literature describing lupus-related misinformation was minimal, with only three manuscripts identified. Conversely, a variety of points of misinformation were identified online and on social media. Key themes identified in online content included suggestion of incorrect causes such as infection or aspartame consumption, false risk assessments such as lupus never developing in males, false claims about conventional treatments, and promotion of alternative treatments or “cures” without evidence. Conclusion: Dermatologists, rheumatologists, and all clinicians treating patients with lupus play an essential role in dispelling the pervasive misinformation surrounding the disease and its treatments, encouraging patients to seek reliable sources of information, and advocating for evidence-based guidance.
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    Reference centiles for infant sleep parameters from 4 to 16 weeks of age: findings from an Irish cohort
    (BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health, 2023-03-21) O'Sullivan, Marc Paul; Livingstone, Vicki; Korotchikova, Irina; Dempsey, Eugene M.; Murray, Deirdre M.; Boylan, Geraldine B.; Science Foundation Ireland; Johnson and Johnson
    Objectives: To establish unconditional reference centiles for sleep parameters in infants 4–16 weeks of age. Design and setting: Secondary data analysis of sleep parameters recorded at 4–16 weeks of age in a longitudinal randomised controlled trial (RCT) (BabySMART). Patients: Healthy term infants assigned to the non-intervention arm of the RCT. Main outcome measures: Infants’ sleep duration was recorded by parents/guardians daily, from week 2–16 of age using a sleep diary. Reference centiles for total, daytime, night-time and longest sleep episode duration were estimated using multilevel modelling. Results: One hundred and six infants, mean (SD) gestational age of 39.9 (1.2) weeks and mean (SD) birth weight of 3.6 (0.5) kg had sleep recorded contributing 1264 measurements for each sleep parameter. Between 4 and 16 weeks of age total sleep duration in a 24-hour period, night-time sleep duration in a 12-hour period and infant’s longest sleep episode duration increased, while daytime sleep duration in a 12-hour period decreased. Conclusions: Reference centiles up to 4 months of age in infants highlight the gradual decrease in daytime sleep and large increases in night-time sleep, which occur in tandem with increasing lengths of sleep episodes. These reference centiles provide useful sleep values for infant sleep trajectory occurring in early life and may be helpful for parents and clinicians.
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    Shared and fragmented understandings in interorganizational IT project teams: An interpretive case study
    (Elsevier, 2021-08-05) McCarthy, Stephen; O'Raghallaigh, Paidi; Fitzgerald, Ciara; Adam, Frédéric
    Shared understanding is essential in interorganizational projects to integrate the divergent knowledge of individual team members and support collaborative knowledge building. This can nevertheless be a challenging undertaking in interorganizational projects as team members must continuously negotiate differences in their organizational and professional backgrounds during project work. In this paper, we explore how interorganizational IT project teams deal with sources of ‘fragmentation’ in their understanding, explicating the theoretical and practical implications that these have for project management. Our study is needed to explore the increasingly complex and emergent nature of interorganizational project management today where neither goals nor the means of attainment are known with precision at a project's launch. We analyze interpretive case study findings from an 8-month IT project involving diverse organizations from industry, academia, and healthcare. Based on our findings, we develop a framework which highlights the relationship between three sources of fragmentation of understanding (interpersonal, technical, and contextual) across key project activities. We contribute towards project management literature by revealing how these sources of fragmentation might be overcome through framing project activities (the problem, method, and solution formulation) differently. While fragmentation may characterize any, or all, of these key activities, it is not without remedy.
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    Microbiome-immune interactions and relationship to asthma severity
    (Elsevier Inc., 2021-12-22) Trujillo, Juan; Lunjani, Nonhlanhla; Ryan, Dermot; O’Mahony, Liam
    Microbial-derived factors are integral components of the molecular circuitry that regulates immune and metabolic functions required for host fitness and survival. Recent advances in culture-based methods and sequencing technologies have revealed previously unappreciated complex communities of bacteria, fungi, and viruses that inhabit the respiratory tract and whose composition and activity are correlated with acute and chronic inflammatory responses. In this article, we will summarize our knowledge to date on the role of the microbiota in severe asthma, acknowledging that data specific to severe asthma are currently limited.
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    All Island Congenital Heart Network brings diagnosis closer to home
    (Irish Medical Organisation, 2022-12) Finn, Daragh; Allawendy, S.A.A.; Dempsey, Eugene M.; McMahon, C. J.
    Aim: The All-Island congenital heart network appointed paediatricians with expertise in cardiology in regional centres. Prior to these appointments children with suspected congenital heart disease were referred to the national children’s heart centre for investigation. The aim of this study is to quantify paediatric cardiology activity in a regional Irish centre over the first year of service provision. Methods: Data was collected retrospectively on all inpatient neonatal referrals over a 12-month period (January 2019 to January 2020). Results: There were 268 neonatal referrals. Premature infants (< 37 weeks gestation) accounted for 26% (n= 69) of total neonatal referrals. Congenital cardiac disease was identified in 58.5% (n= 113) of referrals. Cardiac intervention in the first year of life was required in 24 infants, 12.2% of referrals (5.6% catheter and 6.6% surgery). Discussion: Our report displays how clinical networks of care can reduce hospital transfers from regional neonatal centres for non-invasive cardiology investigations.