Tyndall National Institute - Book Chapters

Permanent URI for this collection

https://hdl.handle.net/10468/3240

Browse

Now showing 1 - 5 of 6

Pushing the limits of kT/C noise in Delta-Sigma Modulators
(Springer Nature Ltd., 2023-06-23) Kalogiros, Spyridon; Salgado, Gerardo; Lyden, Colin; McCarthy, Kevin; O’Connell, Ivan
Thermal noise, which is sampled and aliases in-band in discrete-time systems, limits the achievable performance of switched-capacitor noise-shaping Analog-to-Digital Converters (ADCs). While the performance of such ADCs has advanced significantly over the last 20 years, as quantified by the Schreier figure of merit (FoMS), the theoretical limit of 192 dB remains unchallenged. Over that period, the envelope of ADC performance has advanced from a FoMS of 163 dB, 20 years ago, to 186 dB today, with a rate of advancement, corresponding to ADC performance, which is doubling every 1.6 years. However, this rate of advancement has started to slow in recent years. This chapter will review some of the recent advancements in relation to reducing the thermal noise in switched-capacitor Delta-Sigma Modulators. In addition, this chapter will address many of the challenges associated with breaking the 192 dB FoMS performance barrier.
Wearable technology supported home rehabilitation services in rural areas: emphasis on monitoring structures and activities of functional capacity. Handbook
(Publications of Karelia University of Applied Sciences B, 2019-10) Alamäki, Antti; Nevala, Elina; Barton, John; Condell, Joan; Munoz Esquivel. Karla; Nordström, Anna; Tedesco, Salvatore; Kelly, Daniel; Heaney. David; Tyndall National Institute, Cork Ireland; Ulster University; University College Cork; Västerbotten Läns Landsting; Umeå Universitet; Karelia University of Applied Sciences, Finland; European Regional Development Fund
The sustainability of modern healthcare systems is under threat. – the ageing of the population, the prevalence of chronic disease and a need to focus on wellness and preventative health management, in parallel with the treatment of disease, pose significant social and economic challenges. The current economic situation has made these issues more acute. Across Europe, healthcare expenditure is expected to rice to almost 16% of GDP by 2020. (OECD Health Statistics 2018). Coupled with a shortage of qualified personnel, European nations are facing increasing challenges in their ability to provide better-integrated and sustainable health and social services. The focus is currently shifting from treatment in a care center to prevention and health promotion outside the care institute. Improvements in technology offers one solution to innovate health care and meet demand at a low cost. New technology has the potential to decrease the need for hospitals and health stations (Lankila et al., 2016. In the future the use of new technologies – including health technologies, sensor technologies, digital media, mobile technology etc. - and digital services will dramatically increase interaction between healthcare personnel and customers (Deloitte Center for Health Solutions, 2015a; Deloitte Center for Health Solutions 2015b). Introduction of technology is expected to drive a change in healthcare delivery models and the relationship between patients and healthcare providers. Applications of wearable sensors are the most promising technology to aid health and social care providers deliver safe, more efficient and cost-effective care as well as improving people’s ability to self-manage their health and wellbeing, alert healthcare professionals to changes in their condition and support adherence to prescribed interventions. (Tedesco et al., 2017; Majumder et al., 2017). While it is true that wearable technology can change how healthcare is monitored and delivered, it is necessary to consider a few things when working towards the successful implementation of this new shift in health care. It raises challenges for the healthcare systems in how to implement these new technologies, and how the growing amount of information in clinical practice, integrates into the clinical workflows of healthcare providers. Future challenges for healthcare include how to use the developing technology in a way that will bring added value to healthcare professionals, healthcare organizations and patients without increasing the workload and cost of the healthcare services. For wearable technology developers, the challenge will be to develop solutions that can be easily integrated and used by healthcare professionals considering the existing constraints. This handbook summarizes key findings from clinical and laboratory-controlled demonstrator trials regarding wearables to assist rehabilitation professionals, who are planning the use of wearable sensors in rehabilitation processes. The handbook can also be used by those developing wearable sensor systems for clinical work and especially for use in hometype environments with specific emphasis on elderly patients, who are our major health care consumers.
Mesoporous materials as templates for semiconductor nanowires assembly
(IOS Press, 2003) Holmes, Justin D.; Morris, Michael A.; Ryan, Kevin M.; European Commission; Intel Corporation; Intel Ireland Ltd.
In this chapter is described a novel approach for synthesizing mesoporous silicas with tunable pore diameters, wall thickness and pore spacings that can be used as templates for the assembly of semiconductor nanowire arrays. Silicon and germanium nanowires, with size monodisperse diameters, can readily be formed within the mesoporous silica matrix using a supercritical fluid inclusion technique. These nano-composite materials display unique optical properties such as intense room temperature ultraviolet and visible photoluminescence. The implication of these mesoporous nanowire materials for future electronic and opto-electronic devices is discussed.
Bioconjugated gold nanoparticles enhance siRNA delivery in prostate cancer cells
(Springer, 2019-05-17) Rahme, Kamil; Guo, Jianfeng; Holmes, Justin D.; Dinesh Kumar, Lekha; Science Foundation Ireland; Irish Research Council; Department of Science and Technology of Jilin Province; National Council for Scientific Research
Here we describe a simple way to create a gold nanoparticle (AuNP)-based non-viral delivery system to deliver siRNA into prostate cancer cells. Therefore, positively charged polyethylenimine (PEI)-capped AuNPs were synthesized in water and further conjugated with the targeting ligand (folic acid) for folate receptors (AuNPs-PEI-FA). The AuNPs-PEI-FA could effectively complex small interfering RNA (siRNA) through electrostatic interaction. Flow cytometry displayed that AuNPs-PEI-FA could specifically deliver siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate-specific membrane antigen (PSMA) that exhibits a hydrolase enzymatic activity with a folate substrate. In contrast, internalization of siRNA into PC-3 cells, a prostate cancer cell line not expressing PSMA or folate receptors, was not achieved using AuNPs-PEI-FA.siRNA. Following endolysosomal escape, the AuNPs-PEI-FA-.siRNA formulation resulted in significant endogenous gene silencing when compared to the nontargeted formulation, suggesting the potential of AuNPs-PEI-FA for targeted delivery of therapeutic siRNAs in the treatment of prostate cancer.
Organometallic-metallic-cyclotriphosphazene mixtures: solid state method for metallic nanoparticle growth
(Nova Science Publishers, 2013-04) Díaz, Carlos; Valenzuela, María Luisa; O'Dwyer, Colm; Roger Dong; Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica
We review a recent general solid state method to obtain metallic, metal oxide and phosphate nanoparticles and crystals by pyrolysis at 800°C using organometallic derivatives of cyclo and polyphosphazene precursors containing diverse organometallic fragments linked to polymeric or oligomeric phosphazenes. When the preparation of the molecular precursor is not possible or results in low yield, an alternative method using solid state mixtures of the type MLn/N3P3[O2C12H8]n, where MLn can be a single metallic salt, and a coordination compound or an organometallic, is possible. For AuCl(PPh3)/[NP(O2C12H8)]n mixtures, single crystal cubic Au nanoparticles form, whose morphology, crystal shape, size and distribution strongly depends on deposition quantity and the mixture molar ratio. Nanoparticles as small as 3.5 nm are observed if the mixture is prepared in a crucible and varied geometries of microcrystals found when the mixture was deposited on Si or SiO2 wafers, including single-crystal gold fullerene structures. Extension to Ag, Pd and Re-containing precursor mixtures such as Ag(PPh3)(CF3SO3)/ [NP(O2C12H8)]3, PdCl2/N3P3[O2C12H8]3, and KReO4/N3P3[O2C12H8]3 allows microcrystal formation during pyrolysis. A thermally induced phase demixing mechanism describes the evolution of the crystal growth, aided microphase separation of the polymer mixture. This microphase demixing is shown to be an overarching mechanism involved in the nano to micro scale growth of crystals. A probable mechanism of the atomic and molecular-level chemistry is also proposed based on decomposition of the macromolecular polymeric, trimer and oligomeric precursors for the initial stages.

Browse

Recent Submissions