• Targeting transcription-regulating cyclin dependent kinase 12 for the treatment of breast cancer 

  Burns, Martha (University College Cork, 2022-11-27)

  Cyclin-dependent Kinase 12 (CDK12) with its binding partner Cyclin K regulates transcription through phosphorylation of RNA Polymerase II (RNA Pol II) at serine 2. Previous work showed that inhibition of CDK12 leads to ...
• Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis 

  O'Brien, Ciara (University College Cork, 2021-05-04)

  The presenilin proteins (presenilin 1 and presenilin 2) were identified in mutagenesis screens causing the early onset forms of familial Alzheimer’s disease (FAD) in 1995. Subsequently characterized as the catalytic subunits ...
• Regulation of insulin-like growth factor receptor activity and its therapeutic targeting in cancer 

  Rieger, Leonie (University College Cork, 2020-04-08)

  Insulin-like Growth Factor-1 Receptor signalling is essential for cell growth, and also promotes migration, survival and cellular transformation, thus, linking it to cancer progression. IGF-1R activity and signalling in ...
• In silico-aided design, build and test of synthetic proteins 

  Yallapragada, V. V. B. (University College Cork, 2019-12-20)

  Since the discovery of proteins in 1838, the field of protein engineering and our understanding of proteins have improved exponentially. Synthetic proteins have found applications in various biomedical, food and material-based ...

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