Liquid lens confocal microscopy with advanced signal processing for higher resolution 3D imaging

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dc.contributor.author Riza, Nabeel A.
dc.contributor.author Sheikh, Mumtaz A.
dc.date.accessioned 2020-06-02T12:37:44Z
dc.date.available 2020-06-02T12:37:44Z
dc.date.issued 2009-03-13
dc.identifier.citation Riza, N. A. and and Sheikh, M. A. (2009) 'Liquid lens confocal microscopy with advanced signal processing for higher resolution 3D imaging', Proceedings of SPIE, 7258, Medical Imaging 2009: Physics of Medical Imaging, 725848, SPIE Medical Imaging, Lake Buena Vista (Orlando Area), Florida, United States, 13 March. doi: 10.1117/12.811338 en
dc.identifier.volume 7258 en
dc.identifier.startpage 1 en
dc.identifier.endpage 13 en
dc.identifier.issn 0277-786X
dc.identifier.uri http://hdl.handle.net/10468/10106
dc.identifier.doi 10.1117/12.811338 en
dc.description.abstract The paper first highlights the use of multiple electronically controlled optical lenses, specifically, liquid lenses to realize an axial scanning confocal microscope with potentially less aberrations. Next, proposed is a signal processing method for realizing high resolution three dimensional (3-D) optical imaging using diffraction limited low resolution optical signals. Using axial shift-based signal processing via computer based computation algorithm, three sets of high resolution optical data is determined along the axial (or light beam propagation) direction using low resolution axial data. The three sets of low resolution data are generated by illuminating the 3-D object under observation along its three independent and orthogonal look directions (i.e., x, y, and z) or by physically rotating the object by 90 degrees and also flipping the object by 90 degrees. The three sets of high resolution axial data is combined using a unique mathematical function to interpolate a 3-D image of the test object that is of much higher resolution than the diffraction limited direct measurement 3-D resolution. Confocal microscopy or optical coherence tomography (OCT) are example methods to obtain the axial scan data sets. The proposed processing can be applied to any 3-D wave-based 3-D imager including ones using electromagnetic waves and sound (ultrasonic) waves. Initial computer simulations are described to test the robustness of the proposed high resolution signal processing method en
dc.description.sponsorship European Commission (EU 2008 Eramus Mundus Opt-Sci Program) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Society of Photo-Optical Instrumentation Engineers (SPIE) en
dc.rights © 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. en
dc.subject Image resolution en
dc.subject Confocal microscopy en
dc.subject 3D image processing en
dc.subject Microscopes en
dc.subject Signal processing en
dc.subject Optical resolution en
dc.subject Diffraction en
dc.title Liquid lens confocal microscopy with advanced signal processing for higher resolution 3D imaging en
dc.type Conference item en
dc.internal.authorcontactother Nabeel Riza, Electrical & Electronic Engineering, University College Cork, Cork, Ireland. +353-21-490-3000 Email: n.riza@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder European Commission en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Proceedings of SPIE en
dc.internal.conferencelocation Lake Buena Vista (Orlando Area), Florida, United States en
dc.internal.IRISemailaddress n.riza@ucc.ie en
dc.identifier.articleid 725848 en
dc.identifier.eissn 1996-756X


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