The association between preeclampsia and childhood development and behavioural outcomes

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dc.contributor.author Maher, Gillian M.
dc.contributor.author O'Keeffe, Gerard W.
dc.contributor.author O'Keeffe, Linda M.
dc.contributor.author Matvienko-Sikar, Karen
dc.contributor.author Dalman, Christina
dc.contributor.author Kearney, Patricia M.
dc.contributor.author McCarthy, Fergus P.
dc.contributor.author Khashan, Ali S.
dc.date.accessioned 2020-07-02T09:38:04Z
dc.date.available 2020-07-02T09:38:04Z
dc.date.issued 2020-04-11
dc.identifier.citation Maher, G. M., O'Keeffe, G. W., O'Keeffe, L. M., Matvienko-Sikar, K., Dalman, C., Kearney, P. M., McCarthy, F. P. and Khashan, A. S. (2020) 'The association between preeclampsia and childhood development and behavioural outcomes', Maternal and Child Health Journal, 24(6), pp. 727-738. doi: 10.1007/s10995-020-02921-7 en
dc.identifier.volume 24 en
dc.identifier.issued 6 en
dc.identifier.startpage 727 en
dc.identifier.endpage 738 en
dc.identifier.issn 1092-7875
dc.identifier.uri http://hdl.handle.net/10468/10195
dc.identifier.doi 10.1007/s10995-020-02921-7 en
dc.description.abstract Objectives: To examine the associations between preeclampsia and longitudinal child developmental and behavioural outcomes using data from a nationally representative study of children living in Ireland. Methods: We used maternal-reported data from the Growing Up in Ireland longitudinal study of children. Data on preeclampsia and preeclampsia + small for gestational age (SGA) were collected when children were 9-months old. Data on child development and behavioural outcomes were collected at 9-months using the Ages and Stages Questionnaire (ASQ), and at 3 years, 5 years and 7–8 years using the Strengths and Difficulties Questionnaire (SDQ). Multivariate logistic regression analysis was used to examine the association between preeclampsia exposure and failure of ASQ domains, and abnormal SDQ domains. Linear spline multilevel models were used to examine the association between preeclampsia and preeclampsia + SGA and repeated measures of SDQ. All models controlled for several perinatal and sociodemographic factors. Results: A total of 10,692 children were included in the study at baseline, representing a weighted total of 70,791. Multivariate logistic regression suggested that preeclampsia was not associated with failing any ASQ domain. Preeclampsia was associated with abnormal SDQ cut-off of emotional (≥ 5) and hyperactivity (≥ 7) domains at age 5 years only. In the linear spline model, mean SDQ score was higher at each time point in exposed groups. Conclusions for Practice: While we did not find strong evidence of associations between preeclampsia and child developmental and behavioural outcomes overall, some associations between preeclampsia-exposure and subtle behavioural issues did persist. Further research is needed to replicate these findings, and determine the clinical significance of changes in SDQ scores. en
dc.description.sponsorship Health Research Board (SPHeRE/2013/1) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Switzerland AG en
dc.rights © 2020, Springer Science+Business Media, LLC, part of Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Maternal and Child Health Journal. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10995-020-02921-7 en
dc.subject Preeclampsia en
dc.subject Childhood development en
dc.subject Behavioural issues en
dc.subject Epidemiology en
dc.title The association between preeclampsia and childhood development and behavioural outcomes en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gillian Maher, Infant Research Centre, University College Cork, Cork, Ireland. +353-21-490-3000 Email: gillian.maher@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-04-11
dc.date.updated 2020-07-02T09:15:05Z
dc.description.version Accepted Version en
dc.internal.rssid 522472314
dc.contributor.funder Health Research Board en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Maternal and Child Health Journal en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress gillian.maher@ucc.ie en
dc.identifier.eissn 1573-6628


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