Intramammary infusion of a live culture of Lactococcus lactis for treatment of bovine mastitis: comparison with antibiotic treatment in field trials

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dc.contributor.author Klostermann, Katja
dc.contributor.author Crispie, Fiona
dc.contributor.author Flynn, James
dc.contributor.author Ross, R. Paul
dc.contributor.author Hill, Colin
dc.contributor.author Meaney, William
dc.date.accessioned 2013-04-08T15:24:57Z
dc.date.available 2013-04-08T15:24:57Z
dc.date.copyright 2008-04
dc.date.issued 2008-04
dc.identifier.citation Klostermann, K., F. Crispie, et al. (2008). Intramammary infusion of a live culture of Lactococcus lactis for treatment of bovine mastitis: comparison with antibiotic treatment in field trials. Journal of Dairy Research, 75(3): 365-373. en
dc.identifier.volume 75 en
dc.identifier.issued 3 en
dc.identifier.startpage 365 en
dc.identifier.endpage 373 en
dc.identifier.uri http://hdl.handle.net/10468/1030
dc.identifier.doi 10.1017/S0022029908003373
dc.description.abstract A treatment containing a live food-grade organism, Lactococcus lactis DPC3147, was compared with conventional antibiotic therapy for its potential to treat bovine chronic subclinical or clinical mastitis in two separate field trials. Effects on disease symptoms and bacteriology were monitored in response to infusion with the culture in each trial. In the first trial, the live culture treatment was compared with an intramammary antibiotic (n=11 quarters for each treatment). Results from this small trial demonstrated that the live culture had potential to be as effective at eliminating chronic subclinical infections as an antibiotic treatment. By day 12, 7 of the 11 quarters treated with the live culture were pathogen-free compared with 5 of the 11 antibiotic-treated infected quarters. Somatic cell counts (SCC) remained relatively unchanged regardless of treatment: average log SCC pre- and post-treatment in the lactococci-treated group were 6·33±0·41 (day 0) and 6·27±0·43 cells/ml (day 12) and average log SCC pre- and post-treatment in the antibiotic-treated group were 6·34±0·37 and 6·22±0·46 cells/ml on day 0 and on day 12, respectively. In the second trial, the live culture was compared with an intramammary antibiotic for the treatment of naturally occurring clinical mastitis cases (n=25 quarters for each treatment). Following a 14-d experimental period, similar bacteriological responses were observed in 7 out of 25 live culture treated quarters and 9 out of 25 antibiotic-treated quarters. Additionally, 15 of 25 cases treated with the culture and 18 of 25 cases treated with the antibiotic did not exhibit clinical signs of the disease following treatment. The results of these trials suggest that live culture treatment with Lc. lactis DPC3147 may be as efficacious as common antibiotic treatments in some instances. en
dc.description.sponsorship Science Foundation Ireland (SFI-CSET) en
dc.description.sponsorship European Commission (QLK1-CT-2000-01376 (Nutra Cells)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Cambridge University Press en
dc.relation.uri http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=2004584
dc.rights © Proprietors of Journal of Dairy Research 2008 en
dc.subject Live en
dc.subject Lactococcus lactis en
dc.subject Treatment en
dc.subject Mastitis en
dc.subject.lcsh Microbiology. en
dc.title Intramammary infusion of a live culture of Lactococcus lactis for treatment of bovine mastitis: comparison with antibiotic treatment in field trials en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://research.ucc.ie/profiles/D010/chill
dc.internal.authorcontactother Colin Hill, Alimentary Pharmabiotic Centre, University College Cork, Cork. E-mail: c.hill@ucc.ie
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.rssid 121848197
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder European Commission
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Dairy Research en
dc.internal.IRISemailaddress p.ross@ucc.ie en


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