Vitamin D in pregnancy: Where we are and where we should go

Show simple item record

dc.contributor.author Kiely, Mairead E.
dc.contributor.author Wagner, C. L.
dc.contributor.author Roth, D. E.
dc.date.accessioned 2020-07-27T13:17:55Z
dc.date.available 2020-07-27T13:17:55Z
dc.date.issued 2020-04-14
dc.identifier.citation Kiely, M. E., Wagner, C. L. and Roth, D. E. (2020) 'Vitamin D in pregnancy: Where we are and where we should go', Journal of Steroid Biochemistry and Molecular Biology, 201, 105669 (9pp). doi: 10.1016/j.jsbmb.2020.105669 en
dc.identifier.volume 201 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 0960-0760
dc.identifier.uri http://hdl.handle.net/10468/10311
dc.identifier.doi 10.1016/j.jsbmb.2020.105669 en
dc.description.abstract Vitamin D deficiency has been widely reported among pregnant women and infants around the world. Women with low sun exposure, high BMI, low vitamin D intakes and socioeconomic disadvantage with poor quality diets are at greatest risk of vitamin D deficiency, leading to very low serum concentrations of 25-hydroxyvitamin D (25(OH)D) in their offspring and an increased risk of nutritional rickets. Many observational studies, supported by compelling in vitro and in vivo data, have generated evidence suggesting that low vitamin D status in pregnancy may also contribute to the risk of adverse perinatal outcomes including hypertensive disorders (e.g., preeclampsia), fetal growth restriction, and preterm birth. However, the few large randomized controlled trials (RCTs) conducted to date have generated conflicting evidence for a role of vitamin D supplementation in improving perinatal outcomes. Vitamin D supplementation policies during pregnancy and implementation of policies vary within and between jurisdictions. Regulatory authorities have cited insufficient evidence to establish pregnancy-specific targets for serum 25(OH)D concentrations or prenatal vitamin D intake that effectively reduce the risks of adverse perinatal and infant outcomes. This paper arises from a Debate on Vitamin D Requirements during Pregnancy, held at the 22nd Vitamin D Workshop, 2019. From varied perspectives, our objectives were to evaluate the evidence for: vitamin D metabolism in pregnancy and the prevalence of gestational vitamin D deficiency worldwide; the translation of laboratory research findings to clinical studies on the role of vitamin D in perinatal health; the challenges of designing and conducting clinical trials to establish prenatal vitamin D requirements; and results to date of major large RCTs of prenatal vitamin D supplementation. Lastly, we explored potential next steps towards generating robust clinical data in this field to address both public health protection and patient care. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd. en
dc.rights © 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Perinatal health en
dc.subject Pregnancy en
dc.subject Vitamin D en
dc.subject Vitamin D requirements en
dc.subject Vitamin D status en
dc.title Vitamin D in pregnancy: Where we are and where we should go en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Mairead Kiely, Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: m.kiely@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-04-14
dc.date.updated 2020-07-27T13:09:00Z
dc.description.version Accepted Version en
dc.internal.rssid 511944210
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Steroid Biochemistry and Molecular Biology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress m.kiely@ucc.ie en
dc.identifier.articleid 105669 en
dc.identifier.eissn 1879-1220


Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement