The microbiota-gut-brain axis

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dc.contributor.author Cryan, John F.
dc.contributor.author O'Riordan, Kenneth J.
dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Sandhu, Kiran V.
dc.contributor.author Bastiaanssen, Thomaz F. S.
dc.contributor.author Boehme, Mcusra
dc.contributor.author Codagnone, Martin G.
dc.contributor.author Cussotto, Sofia
dc.contributor.author Fulling, Christine
dc.contributor.author Golubeva, Anna V.
dc.contributor.author Guzzetta, Katherine E.
dc.contributor.author Jaggar, Minal
dc.contributor.author Long-Smith, Caitriona M. .
dc.contributor.author Lyte, Joshua M.
dc.contributor.author Martin, Jason A.
dc.contributor.author Molinero-Perez, Alicia
dc.contributor.author Moloney, Gerard
dc.contributor.author Morelli, Emanuela
dc.contributor.author Morillas, Enrique
dc.contributor.author O'Connor, Rory
dc.contributor.author Cruz-Pereira, Joana S.
dc.contributor.author Peterson, Veronica L.
dc.contributor.author Rea, Kieran
dc.contributor.author Ritz, Nathaniel L.
dc.contributor.author Sherwin, Eoin
dc.contributor.author Spichak, Simon
dc.contributor.author Teichman, Emily M.
dc.contributor.author van de Wouw, Marcel
dc.contributor.author Ventura-Silva, Ana Paula
dc.contributor.author Wallace-Fitzsimons, Shauna E.
dc.contributor.author Hyland, Niall
dc.contributor.author Clarke, Gerard
dc.contributor.author Dinan, Timothy G.
dc.date.accessioned 2020-09-10T13:11:42Z
dc.date.available 2020-09-10T13:11:42Z
dc.date.issued 2019-08-28
dc.identifier.citation Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., Guzzetta, K. E., Jaggar, M., Long-Smith, C. M., Lyte, J. M., Martin, J. A., Molinero-Perez, A., Moloney, G., Morelli, E., Morillas, E., O'Connor, R., Cruz-Pereira, J. S., Peterson, V. L., Rea, K., Ritz, N. L., Sherwin, E., Spichak, S., Teichman, E. M., Wouw, M. v. d., Ventura-Silva, A. P., Wallace-Fitzsimons, S. E., Hyland, N., Clarke, G. and Dinan, T. G. (2019) 'The Microbiota-Gut-Brain Axis', Physiological Reviews, 99(4), pp. 1877-2013. doi: 10.1152/physrev.00018.2018 en
dc.identifier.volume 99 en
dc.identifier.issued 4 en
dc.identifier.startpage 1877 en
dc.identifier.endpage 2013 en
dc.identifier.issn 0031-9333
dc.identifier.uri http://hdl.handle.net/10468/10506
dc.identifier.doi 10.1152/physrev.00018.2018 en
dc.description.abstract The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson's disease, and Alzheimer's disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders. en
dc.description.sponsorship Health Research Board of Ireland (Grants HRA_POR/2011/23 and HRA_POR/2012/32); Science Foundation Ireland (Joint Programming Initiative-a healthy diet for a healthy life (JPI-HDHL)-investigating Nutrition and Cognitive Function (NutriCog) by SFI Grant “A Menu for Brain Responses Opposing Stress-Induced Alternations in Cognition” (AMBROSIAC) 15/JP-HDHL/3270, as well as the Joint Programming Initiative “HEALTHMARK: Metabolic HEALTH through nutrition, microbiota and tryptophan bioMARKers,” 16/ERA-HDHL/3362 ); Irish Health Research Board (Grant ILP-POR-2017-013); Irish Research Council (Postgraduate Scholarships GOIPG/2019/3198, GOIPG/2018/2560) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Physiological Society en
dc.relation.uri https://journals.physiology.org/doi/full/10.1152/physrev.00018.2018
dc.rights © 2019 the American Physiological Society en
dc.subject Brain-gut en
dc.subject Microbiome en
dc.subject Neurogastroenterology en
dc.subject Second brain en
dc.subject Stress en
dc.title The microbiota-gut-brain axis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F Cryan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2020-09-10T12:48:25Z
dc.description.version Accepted Version en
dc.internal.rssid 499903990
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder Department of Agriculture, Food and the Marine, Ireland en
dc.contributor.funder Irish Research Council en
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Physiological reviews en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.cryan@ucc.ie en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.internal.IRISemailaddress g.clarke@ucc.ie en
dc.internal.IRISemailaddress thomaz.bastiaanssen@ucc.ie en
dc.internal.IRISemailaddress ken.oriordan@ucc.ie en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.internal.IRISemailaddress g.moloney@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEX en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/797592/EU/Gut microbiota-Microglia Interactions in NeuroDevelopment/GutMIND en
dc.identifier.eissn 1522-1210


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