The non-drug management of patients with chronic gastrointestinal disease

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dc.contributor.advisor Shanahan, Fergus en
dc.contributor.advisor Maher, Michael M. en O'Grady, John 2020-09-16T08:11:37Z 2020-09-16T08:11:37Z 2020-08-11 2020-08-11
dc.identifier.citation O'Grady, J. 2020. The non-drug management of patients with chronic gastrointestinal disease. MD Thesis, University College Cork. en
dc.identifier.endpage 216 en
dc.description.abstract The work embodied in this thesis explores various aspects of health for patients with chronic gastrointestinal disease. By analysing additional factors to the primary disease component, such as inflammatory bowel disease, it is hoped that the overall health of such patients may be improved. Dietary fibre in health is reviewed in the modern era of microbial science, and in the context of low mean daily fibre intake among patients with Crohns disease of 13.9g/day. In addition, a rise in BMI over a ten year period is demonstrated among patients with Crohns disease. This rise in abnormal metabolic health appears independent of biologic drugs now commonly prescribed. Furthermore, we demonstrate a low radiation dose CT protocol using model based iterative reconstruction, to reduce effects of radiation exposure associated with high BMI, to be an effective first-line imaging modality without image compromise. To mitigate effects of medication sideeffects using non-drug therapies, we show, using video capsule endoscopy (VCE), that Bifidobacterium 195 mitigated effects of Aspirin-induced small bowel damage. Finally, using VCE, we demonstrate median gastric and small bowel transit times of 22 minutes, interquartile range (IQR) 10-48 minutes, and 198.5 minutes, IQR 157- 240.5 minutes respectively. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2020, John O'Grady. en
dc.rights.uri en
dc.subject Dietary fibre en
dc.subject Body mass index en
dc.subject Metabolic health en
dc.subject Inflammatory bowel disease en
dc.subject Low radiation computed tomography en
dc.subject Video capsule endoscopy en
dc.subject Gastrointestinal transit time en
dc.title The non-drug management of patients with chronic gastrointestinal disease en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname MD - Doctor of Medicine en
dc.internal.availability Full text not available en
dc.description.version Accepted Version en
dc.description.status Not peer reviewed en Medicine en
dc.internal.conferring Autumn 2020 en
dc.internal.ricu APC Microbiome Institute en
dc.availability.bitstream controlled 2025-08-18

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© 2020, John O'Grady. Except where otherwise noted, this item's license is described as © 2020, John O'Grady.
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