Programmed genetic decoding with an emphasis on translational bypassing

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dc.contributor.advisor Atkins, John F. en
dc.contributor.advisor Baranov, Pavel V. en
dc.contributor.author O'Loughlin, Sinéad
dc.date.accessioned 2020-09-21T10:21:37Z
dc.date.available 2020-09-21T10:21:37Z
dc.date.issued 2020-01
dc.date.submitted 2020-01
dc.identifier.citation O'Loughlin, S. 2020. Programmed genetic decoding with an emphasis on translational bypassing. PhD Thesis, University College Cork. en
dc.identifier.endpage 233 en
dc.identifier.uri http://hdl.handle.net/10468/10559
dc.description.abstract The process of gene expression was long believed to be fixed across all domains of life, set in stone by both the universality of the genetic code and the protein-synthesising machinery that decodes it. However, exceptions are known to exist for a minority of mRNAs which temporarily bend the rules of standard decoding. These exceptions can range from a proportion of ribosomes temporarily changing directionality along an mRNA and realigning to an alternative frame, to ribosomes possessing the ability to subvert translation of a block of nucleotides and resume translation downstream on the mRNA transcript. In further cases, ribosomes can redefine the meaning of a stop or sense codon. This assortment of non-canonical translational events is collectively known as Recoding. It can be further subdivided into several respective categories: frameshifting, bypassing, and redefinition. Recoding events are distinct from standard errors in translation due to the programmed fashion in which they occur, with their efficiency tuned by a set of cis-acting elements located 3’ and/or 5’ of the recode site, as well as by trans-acting factors. Translational recoding is in direct competition with standard decoding, facilitating the synthesis of multiple products from the same mRNA transcript, and thus seamlessly adding an extra layer of information to the proteome. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2020, Sinéad O'Loughlin. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Translation en
dc.subject Recoding en
dc.subject Ribosome en
dc.subject Structure en
dc.subject Bypassing en
dc.subject Frameshifting en
dc.title Programmed genetic decoding with an emphasis on translational bypassing en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD - Doctor of Philosophy en
dc.internal.availability Full text not available en
dc.description.version Accepted Version en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Not peer reviewed en
dc.internal.school Biochemistry and Cell Biology en
dc.internal.conferring Autumn 2020 en
dc.internal.ricu Analytical and Biological Chemistry Research Facility en
dc.availability.bitstream controlled
dc.check.date 2025-08-28


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© 2020, Sinéad O'Loughlin. Except where otherwise noted, this item's license is described as © 2020, Sinéad O'Loughlin.
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