Measurement properties of EQ-5D-3L and EQ-5D-5L in recording self-reported health status in older patients with substantial multimorbidity and polypharmacy

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dc.contributor.author Bhadhuri, Arjun
dc.contributor.author Kind, Paul
dc.contributor.author Salari, Paolo
dc.contributor.author Jungo, Katherine Tabea
dc.contributor.author Boland, Benoît
dc.contributor.author Byrne, Stephen
dc.contributor.author Hossman, Stefanie
dc.contributor.author Dalleur, Olivia
dc.contributor.author Knol, Wilma
dc.contributor.author Moutzouri, Elisavet
dc.contributor.author O'Mahony, Denis
dc.contributor.author Murphy, Kevin D.
dc.contributor.author Wisselink, Linda
dc.contributor.author Rodondi, Nicolas
dc.contributor.author Schwenkglenks, Matthias
dc.date.accessioned 2020-10-21T13:20:57Z
dc.date.available 2020-10-21T13:20:57Z
dc.date.issued 2020-09-29
dc.identifier.citation Bhadhuri, A., Kind, P., Salari, P., Jungo, K. T., Boland, B., Byrne, S., Hossmann, S., Dalleur, O., Knol, W., Moutzouri, E., O’Mahony, D., Murphy, K. D., Wisselink, L., Rodondi, N. and Schwenkglenks, M. (2020) 'Measurement properties of EQ-5D-3L and EQ-5D-5L in recording self-reported health status in older patients with substantial multimorbidity and polypharmacy', Health and Quality of Life Outcomes, 18(1), 317 (17 pp). doi: en
dc.identifier.volume 18 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 17 en
dc.identifier.issn 1477-7525
dc.identifier.uri http://hdl.handle.net/10468/10675
dc.identifier.doi 10.1186/s12955-020-01564-0 en
dc.description.abstract Background: The EQ-5D-3L and EQ-5D-5L are two generic health-related quality of life measures, which may be used in clinical and health economic research. They measure impairment in 5 aspects of health: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. The aim of this study was to assess the performance of the EQ-5D-3L and EQ-5D-5L in measuring the self-reported health status of older patients with substantial multimorbidity and associated polypharmacy. Methods: Between 2017 and 2019, we administered EQ-5D-3L and EQ-5D-5L to a subset of patients participating in the OPERAM trial at 6 months and 12 months after enrolment. The OPERAM trial is a two-arm multinational cluster randomised controlled trial of structured medication review assisted by a software-based decision support system versus usual pharmaceutical care, for older people (aged ≥ 70 years) with multimorbidity and polypharmacy. In the psychometric analyses, we only included participants who completed the measures in full at 6 and 12 months. We assessed whether responses to the measures were consistent by assessing the proportion of EQ-5D-5L responses, which were 2 or more levels away from that person’s EQ-5D-3L response. We also compared the measures in terms of informativity, and discriminant validity and responsiveness relative to the Barthel Index, which measures independence in activities of daily living. Results: 224 patients (mean age of 77 years; 56% male) were included in the psychometric analyses. Ceiling effects reported with the EQ-5D-5L (22%) were lower than with the EQ-5D-3L (29%). For the mobility item, the EQ-5D-5L demonstrated better informativity (Shannon’s evenness index score of 0.86) than the EQ-5D-3L (Shannon’s evenness index score of 0.69). Both the 3L and 5L versions of EQ-5D demonstrated good performance in terms of discriminant validity, i.e. (out of all items of the EQ-5D-3L and EQ-5D-5L, the pain/discomfort and anxiety/depression items had the weakest correlation with the Barthel Index. Both the 3L and 5L versions of EQ-5D demonstrated good responsiveness to changes in the Barthel Index. Conclusion: Both EQ-5D-3L and EQ-5D-5L demonstrated validity and responsiveness when administered to older adults with substantial multimorbidity and polypharmacy who were able to complete the measures. en
dc.description.sponsorship Staatssekretariat für Bildung, Forschung und Innovation (Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number 15.0137) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BMC, Part of Springer Nature en
dc.relation.uri https://hqlo.biomedcentral.com/articles/10.1186/s12955-020-01564
dc.rights © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Quality of life measures en
dc.subject EQ-5D-3L en
dc.subject EQ-5D-5L en
dc.subject Multimorbidity en
dc.subject Polypharmacy en
dc.title Measurement properties of EQ-5D-3L and EQ-5D-5L in recording self-reported health status in older patients with substantial multimorbidity and polypharmacy en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Kevin Murphy, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: kevin.murphy@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2020-10-16T16:04:13Z
dc.description.version Published Version en
dc.internal.rssid 538497198
dc.contributor.funder Horizon 2020 en
dc.contributor.funder Staatssekretariat für Bildung, Forschung und Innovation en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Health and Quality of Life Outcomes en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress kevin.murphy@ucc.ie en
dc.internal.IRISemailaddress stephen.byrne@ucc.ie en
dc.internal.IRISemailaddress denis.omahony@ucc.ie en
dc.identifier.articleid 317 en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::RIA/634238/EU/OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly/OPERAM


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© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Except where otherwise noted, this item's license is described as © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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