A prospective study of placental growth factor in twin pregnancy and development of a dichorionic twin pregnancy specific reference range

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dc.contributor.author Hayes-Ryan, Deirdre
dc.contributor.author Meaney, Sarah
dc.contributor.author Fitzgerald, Anthony P.
dc.contributor.author O'Mahony, E.
dc.contributor.author Normile, C.
dc.contributor.author Kenny, Louise C.
dc.contributor.author O'Donogue, Keelin
dc.date.accessioned 2020-10-30T14:11:45Z
dc.date.available 2020-10-30T14:11:45Z
dc.date.issued 2020-09-18
dc.identifier.citation Hayes-Ryan, D., Meaney, S., Fitzgerald, A., O’Mahony, E., Normile, C., Kenny, L. and O’Donoghue, K. (2020) 'A prospective study of placental growth factor in twin pregnancy and development of a dichorionic twin pregnancy specific reference range', BJOG: An International Journal of Obstetrics & Gynaecology, (9 pp). doi: 10.1111/1471-0528.16518 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 1470-0328
dc.identifier.uri http://hdl.handle.net/10468/10688
dc.identifier.doi 10.1111/1471-0528.16518 en
dc.description.abstract Objective: To develop a dichorionic twin pregnancy specific reference range for placental growth factor (PlGF), and to compare gestation‐specific placental growth factor levels in twin pregnancies later complicated by pre‐eclampsia, hypertensive disorder of pregnancy or fetal growth restriction with control pregnancies. Design: Prospective observational study. Setting: Single large tertiary maternity unit in Ireland. Population or Sample: Women with a twin pregnancy. Methods: Consenting pregnant women, across a variety of gestations, had a single blood sample taken at one time‐point only during their pregnancy. The plasma was initially biobanked and PlGF was measured later in batches using the point of care Triage® PlGF test. Main outcome measures: Development of pre‐eclampsia, hypertensive disorder of pregnancy or fetal growth restriction. Results: Placental growth factor levels in uncomplicated dichorionic twin pregnancies were significantly lower in the women who later developed pre‐eclampsia than in the controls at all gestational intervals. In those that later developed any hypertensive disorder of pregnancy, median PlGF was lower only in those recruited before 24 weeks of gestation, whereas in infants with a customised birthweight below the third centile, PlGF was lower only in those sampled after 24 weeks of gestation. Conclusions: Placental growth factor levels in twin pregnancy differ significantly between those women with a pregnancy that will later be complicated by pre‐eclampsia and those that will not. This difference is present many weeks before clinical signs or symptoms of disease are present. Using cross‐sectional values from uncomplicated twin pregnancies, we have developed a dichorionic twin pregnancy specific reference range for PlGF. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.16518
dc.rights © 2020 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: ‘A prospective study of placental growth factor in twin pregnancy and development of a dichorionic twin pregnancy specific reference range’, BJOG 2020, which has been published in final form at https://doi.org/10.1111/1471-0528.16518. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Hypertensive disorders of pregnancy en
dc.subject Placental growth factor en
dc.subject Pre‐eclampsia en
dc.subject Reference range en
dc.subject Twin pregnancy en
dc.title A prospective study of placental growth factor in twin pregnancy and development of a dichorionic twin pregnancy specific reference range en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Deirdre Hayes-Ryan, The Irish Centre for Maternal and Child Health Research (INFANT), Cork, Ireland. +353-21-490-3000 Email: deirdre.hayesryan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-09-18
dc.description.version Accepted Version en
dc.contributor.funder Irish Centre for Maternal and Child Health Research (INFANT), Cork, Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle BJOG: An International Journal of Obstetrics & Gynaecology en
dc.internal.IRISemailaddress deirdre.hayesryan@ucc.ie en
dc.internal.IRISemailaddress s.meaney@ucc.ie en
dc.internal.IRISemailaddress k.odonoghue@ucc.ie en
dc.internal.IRISemailaddress t.fitzgerald@ucc.ie en


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