• Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease 

  Ryan, Fergal J.; Ahern, A. M.; Fitzgerald, R. S.; Laserna-Mendieta, E. J.; Power, E. M.; Clooney, A. G.; O'Donoghue, K. W.; McMurdie, P. J.; Iwai, S.; Crits-Christoph, A.; Sheehan, F.; Moran, C.; Flemer, B.; Zomer, A. L.; Fanning, A.; O'Callaghan, J.; Walton, Janette; Temko, Andriy; Stack, W.; Jackson, L.; Joyce, Susan A.; Melgar, Silvia; DeSantis, Todd Z.; Bell, Bell, Jordana T.; Shanahan, Fergus; Claesson, Marcus J. (Springer Nature, 2020-03-23)

  Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and ...
• Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system 

  Geng, Wenjing; Long, Sarah L.; Chang, Yun-Juan; Saxton, Arnold M.; Joyce, Susan A.; Lin, Jun (Springer Nature, 2020-03-18)

  Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid (BA) modification in the gut. This activity is a promising target for developing innovative non-antibiotic growth promoters to enhance ...
• Beneficial bile acid metabolism from Lactobacillus plantarum of food origin 

  Prete, Roberta; Long, Sarah Louise; Lopez Gallardo, Alvaro; Gahan, Cormac G.; Corsetti, Aldo; Joyce, Susan A. (Springer Nature, 2020-12-24)

  Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit ...
• When rhythms meet the blues: Circadian interactions with the microbiota-gut-brain axis 

  Teichman, Emily M.; O'Riordan, Kenneth J.; Gahan, Cormac G. M.; Dinan, Timothy G.; Cryan, John F. (Elsevier Inc., 2020-03-03)

  The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal ...
• Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome 

  Barrett, Maurice; Hand, Collette K.; Shanahan, Fergus; Murphy, Thomas; O'Toole, Paul W. (Elsevier Inc., 2020-02-20)

  Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes ...

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