APC Microbiome Institute

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APC Microbiome Institute

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  • Ryan, Fergal J.; Ahern, A. M.; Fitzgerald, R. S.; Laserna-Mendieta, E. J.; Power, E. M.; Clooney, A. G.; O'Donoghue, K. W.; McMurdie, P. J.; Iwai, S.; Crits-Christoph, A.; Sheehan, F.; Moran, C.; Flemer, B.; Zomer, A. L.; Fanning, A.; O'Callaghan, J.; Walton, Janette; Temko, Andriy; Stack, W.; Jackson, L.; Joyce, Susan A.; Melgar, Silvia; DeSantis, Todd Z.; Bell, Bell, Jordana T.; Shanahan, Fergus; Claesson, Marcus J. (Springer Nature, 2020-03-23)
    Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and ...
  • Geng, Wenjing; Long, Sarah L.; Chang, Yun-Juan; Saxton, Arnold M.; Joyce, Susan A.; Lin, Jun (Springer Nature, 2020-03-18)
    Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid (BA) modification in the gut. This activity is a promising target for developing innovative non-antibiotic growth promoters to enhance ...
  • Prete, Roberta; Long, Sarah Louise; Lopez Gallardo, Alvaro; Gahan, Cormac G.; Corsetti, Aldo; Joyce, Susan A. (Springer Nature, 2020-12-24)
    Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit ...
  • Teichman, Emily M.; O'Riordan, Kenneth J.; Gahan, Cormac G. M.; Dinan, Timothy G.; Cryan, John F. (Elsevier Inc., 2020-03-03)
    The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal ...
  • Barrett, Maurice; Hand, Collette K.; Shanahan, Fergus; Murphy, Thomas; O'Toole, Paul W. (Elsevier Inc., 2020-02-20)
    Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes ...

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