• Next-generation probiotics: the spectrum from probiotics to live biotherapeutics 

  O'Toole, Paul W.; Marchesi, Julian R.; Hill, Colin (Nature Publishing Group, 2017)

  The leading probiotics currently available to consumers are generally drawn from a narrow range of organisms. Knowledge of the gut microbiota and its constituent actors is changing this paradigm, particularly given the ...
• The impact of body composition parameters on ipilimumab toxicity and survival in patients with metastatic melanoma 

  Daly, Louise E.; Power, Derek G.; O'Reilly, Aine; Donnellan, Paul; Cushen, Samantha J.; O'Sullivan, Kathleen; Twomey, Maria; Woodlock, David P.; Redmond, H. Paul; Ryan, Aoife M. (Nature Publishing Group, 2017)

  Background: Body composition is an important predictor of drug toxicity and outcome. Ipilimumab (Ipi), a monoclonal antibody used to treat metastatic melanoma, has specific toxicities. No validated biomarkers that predict ...
• The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level 

  Barton, Wiley; Penney, Nicholas C.; Cronin, Owen; Garcia-Perez, Isabel; Molloy, Michael G.; Holmes, Elaine; Shanahan, Fergus; Cotter, Paul D.; O'Sullivan, Orla (BMJ Publishing Group, 2018)

  Objective: It is evident that the gut microbiota and factors that influence its composition and activity effect human metabolic, immunological and developmental processes. We previously reported that extreme physical ...
• Fecal microbiota variation across the lifespan of the healthy laboratory rat 

  Flemer, Burkhardt; Gaci, Nadia; Borrel, Guillaume; Sanderson, Ian R.; Chaudhary, Prem P.; Tottey, William; O'Toole, Paul W.; Brugere, Jean-Francois (Taylor & Francis Inc, 2017)

  Laboratory rats are commonly used in life science research as a model for human biology and disease, but the composition and development of their gut microbiota during life is poorly understood. We determined the fecal ...
• Parasite genetic distance and local adaptation in co-evolving bacteria-bacteriophage populations 

  Scanlan, Pauline D.; Hall, Alex R.; Buckling, Angus (Wiley, 2016-10-24)

  Antagonistic co-evolution between hosts and parasites can lead to local adaptation (LA) such that parasite fitness is greatest in sympatric hosts (or vice versa). The magnitude of LA typically increases with geographical ...

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