In recent years, it has been elucidated that, in addition to host genetics, the gut microbiome must be considered as a source of pharmacokinetic variability. As newly emerging drug candidates trend toward low solubility ...
Dietary supplementation with CLA has been reported to alleviate the effect of colitis in mice, but the mechanisms involved need further exploration. The study aimed to investigate how orally administered CLA alleviates ...
Cowan, Caitlin S. M.; Dinan, Timothy G.; Cryan, John F.(Wiley, 2019-11-26)
The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota–gut–brain axis, it is now being recognized that the ...
van de Wouw, Marcel; Lyte, Joshua M.; Boehme, Marcus; Sichetti, Marzia; Moloney, Gerard; Goodson, Michael S.; Kelley-Loughnane, Nancy; Dinan, Timothy G.; Clarke, Gerard; Cryan, John F.(Elsevier, 2019-12-05)
There has been a growing recognition of the involvement of the gastrointestinal microbiota in the development of stress-related disorders. Acute stress leads to activation of neuroendocrine systems, which in turn orchestrate ...
Bifidobacteria are one of the first bacterial genera to colonise the gastrointestinal tract of human infants, are found in breast milk, are reported to influence immunity and to affect susceptibility to infectious and ...
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