Alimentary Pharmabiotic Centre

Alimentary Pharmabiotic Centre


The mission of the Alimentary Pharmabiotic Centre is to link Irish science with industry and society through excellence in research, education and outreach in gastrointestinal health. For further information visit the APC website

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  • Bergmann, Silke; Beard, Philippa M.; Pasche, Bastian; Lienenklaus, Stefan; Weiss, Siegfried; Gahan, Cormac G.; Schughart, Klaus; Lengeling, Andreas (BioMed Central Ltd., 2013-04-23)
    Background: The bacterial surface protein internalin (InlA) is a major virulence factor of the food-born pathogen Listeria monocytogenes. It plays a critical role in the bacteria crossing the host intestinal barrier by a ...
  • Campion, Alicia; Casey, Pat G.; Field, Des; Cotter, Paul D.; Hill, Colin; Ross, R. Paul (BioMed Central Ltd., 2013-02-01)
    Background: Lantibiotics are post-translationally modified antimicrobial peptides, of which nisin A is the most extensively studied example. Bioengineering of nisin A has resulted in the generation of derivatives with ...
  • Molloy, Evelyn M.; Field, Des; O'Connor, Paula M.; Cotter, Paul D.; Hill, Colin; Ross, R. Paul (Public Library of Science, 2013)
    It is becoming increasingly apparent that innovations from the "golden age'' of antibiotics are becoming ineffective, resulting in a pressing need for novel therapeutics. The bacteriocin family of antimicrobial peptides ...
  • Tottey, William; Denonfoux, Jeremie; Jaziri, Faouzi; Parisot, Nicolas; Missaoui, Mohiedine; Hill, David; Borrel, Guillaume; Peyretaillade, Eric; Alric, Monique; Harris, Hugh Michael B.; Jeffery, Ian B.; Claesson, Marcus J.; O'Toole, Paul W.; Peyret, Pierre; Brugère, Jean-François (Public Library of Science, 2013)
    Evaluating the composition of the human gut microbiota greatly facilitates studies on its role in human pathophysiology, and is heavily reliant on culture-independent molecular methods. A microarray designated the Human ...
  • Clarke, Siobhan F.; Murphy, Eileen F.; O'Sullivan, Orla; Ross, R. Paul; O'Toole, Paul W.; Shanahan, Fergus; Cotter, Paul D. (Public Library of Science, 2013)
    Links between the gut microbiota and host metabolism have provided new perspectives on obesity. We previously showed that the link between the microbiota and fat deposition is age-and time-dependent subject to microbial ...

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