Current uses of chlorhexidine for management of oral disease: a narrative review

Show simple item record

dc.contributor.author Brookes, Zoe L. S.
dc.contributor.author Bescos, Raul
dc.contributor.author Belfield, Louise A.
dc.contributor.author Ali, Kamran
dc.contributor.author Roberts, Anthony
dc.date.accessioned 2020-11-10T13:26:57Z
dc.date.available 2020-11-10T13:26:57Z
dc.date.issued 2020-10-17
dc.identifier.citation Brookes, Z. L. S., Bescos, R., Belfield, L. A., Ali, K. and Roberts, A.(2020) 'Current uses of chlorhexidine for management of oral disease: a narrative review', Journal of Dentistry, 103, 103497 (9pp). doi: 10.1016/j.jdent.2020.103497 en
dc.identifier.volume 103 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 1879-176X
dc.identifier.issn 0300-5712
dc.identifier.uri http://hdl.handle.net/10468/10749
dc.identifier.doi 10.1016/j.jdent.2020.103497 en
dc.description.abstract Objectives: Chlorhexidine (CHX) is a commonly used antiseptic mouthwash, used by dental practitioners and the public, due to its antimicrobial effects. The aim of this article was to provide a narrative review of current antimicrobial uses of CHX relevant to dentistry in the context of oral diseases, highlighting need for further studies to support its safe and appropriate use. Study selection, data and sources: Randomised controlled trials, systematic reviews and national (UK and US) guidelines were consulted where available, with search terms for each subject category entered into MEDLINE, PubMed, Google Scholar and the Cochrane database. Results: Some evidence existed to support adjunctive short-term use of CHX to manage dental plaque, and reduce clinical symptoms of gingivitis, dry socket, as well as reduce aerosolisation of bacteria. However, use must be weighed alongside the less desirable effects of CHX, including extrinsic staining of teeth, antimicrobial resistance to antiseptic agents and the rare, but fatal, allergic reactions to CHX. Conversely, evidence for the effectiveness of chlorhexidine to manage or prevent periodontitis, dental caries, necrotising periodontal diseases, peri-implantitis, and infections associated with extraction and aerosolised viruses remains less certain. Conclusions: The use of CHX in dentistry and oral healthcare continues to be widespread and thus it is important that dental practitioners understand that, based on its differential mechanisms of action on different microbes, appropriate clinical and dental use of CHX should be oral disease specific. However, further scientific and clinical research is required before full recommendations can be made. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier B.V. en
dc.rights © 2020, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Chlorhexidine en
dc.subject Mouthwash en
dc.subject Periodontitis en
dc.subject Caries en
dc.subject Bacteria en
dc.subject Virus en
dc.title Current uses of chlorhexidine for management of oral disease: a narrative review en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Anthony Roberts, Restorative Dentistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.roberts@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-10-17
dc.date.updated 2020-11-10T13:15:17Z
dc.description.version Accepted Version en
dc.internal.rssid 542533153
dc.internal.pmid 33075450
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Dentistry en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.roberts@ucc.ie en
dc.identifier.articleid 103497 en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

© 2020, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2020, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement