Diet and depression: exploring the biological mechanisms of action

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dc.contributor.author Marx, Wolfgang
dc.contributor.author Lane, Melissa
dc.contributor.author Hockey, Meghan
dc.contributor.author Aslam, Hajara
dc.contributor.author Berk, Michael
dc.contributor.author Walder, Ken
dc.contributor.author Borsini, Alessandra
dc.contributor.author Firth, Joseph
dc.contributor.author Pariante, Carmine M.
dc.contributor.author Berding, Kirsten
dc.contributor.author Cryan, John F.
dc.contributor.author Clarke, Gerard
dc.contributor.author Craig, Jeffrey M.
dc.contributor.author Su, Kuan-Pin
dc.contributor.author Mischoulon, David
dc.contributor.author Gomez-Pinilla, Fernando
dc.contributor.author Foster, Jane A
dc.contributor.author Cani, Patrice D.
dc.contributor.author Thuret, Sandrine
dc.contributor.author Staudacher, Heidi M.
dc.contributor.author Sánchez-Villegas, Almudena
dc.contributor.author Arshad, Husnain
dc.contributor.author Akbaraly, Tasnime
dc.contributor.author O'Neil, Adrienne
dc.contributor.author Segasby, Toby
dc.contributor.author Jacka, Felice N.
dc.date.accessioned 2020-12-08T17:08:37Z
dc.date.available 2020-12-08T17:08:37Z
dc.date.issued 2020-11-03
dc.identifier.citation Marx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., Borsini, A., Firth, J., Pariante, C. M., Berding, K., Cryan, J. F., Clarke, G., Craig, J. M., Su, K.-P., Mischoulon, D., Gomez-Pinilla, F., Foster, J. A., Cani, P. D., Thuret, S., Staudacher, H. M., Sánchez-Villegas, A., Arshad, H., Akbaraly, T., O’Neil, A., Segasby, T. and Jacka, F. N. (2020) ‘Diet and depression: exploring the biological mechanisms of action’, Molecular Psychiatry. doi: 10.1038/s41380-020-00925-x en
dc.identifier.issn 1359-4184
dc.identifier.uri http://hdl.handle.net/10468/10821
dc.identifier.doi 10.1038/s41380-020-00925-x en
dc.description.abstract The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed. en
dc.description.sponsorship Deakin University (Alfred Deakin Postdoctoral Research Fellowship; PhD Scholarship; Postgraduate Industry Research Scholarship); Multiple Sclerosis Research Australia (Early-Career Fellowship); Australian Rotary Health (PhD Scholarship); NHMRC (Senior Principal Research Fellowship 1059660 and 1156072); UK Medical Research Council (Grants MR/L014815/1; MR/J002739/1; MR/N029488/1); Irish Research Council (Post-doctoral fellowship); Swiss National Foundation (Sinergia grant GUT-BRAIN); Irish Research Council (Postgraduate Scholarship GOIPG/2019/3198; GOIPG/2018/2560); Health Research Board (Grant number ILP-POR-2017-013); University of Manchester (Presidential Fellowship P123958); UK Research and Innovation (Future Leaders Fellowship MR/T021780/1); Australian Research Council (DP190103081); National Health and Medical Research Council (APP114333; APP1079102); Ministry of Science and Technology, Taiwan (MOST 106-2314-B-039-027-MY3; 108-2320-B-039-048; 108-2813-C-039-133-B; 108-2314-B-039-016); National Health Research Institutes, Taiwan (NHRI-EX108-10528NI Universidade de Macau, China (MYRG2018-00242-ICMS); Ministry of Education, Taiwan (CMRC-CMA-3); China Medical University, Taiwan (CMU108-SR-106), China Medical University Hospital, Taiwan (CRS-108-048, DMR-108-216 and DMR-109-102); Fonds Baillet Latour (Grant for Medical Research 2015); Fonds de la Recherche Scientifique (FNRS, FRFS-WELBIO: WELBIO-CR-2019C-02R); ERC (Starting Grant 2013 (336452-ENIGMO); Heart Foundation Australia and Wilson Foundation (Future Leader Fellowship (#101160); Horizon 2020 (Grant SC1-BHC-01-2019); Science Foundation Ireland (SFI/12/RC/2273-P2), (15/JPHDHL/3270); 16/ERAHDHL/3362) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Limited en
dc.rights © 2020, the Authors, under exclusive licence to Springer Nature Limited. This is a post-peer-review, pre-copyedit version of an article published in Molecular Psychiatry on 3 November 2020. The final authenticated version is available online at: https://doi.org/10.1038/s41380-020-00925-x en
dc.subject Diet en
dc.subject Mental health en
dc.subject Nutritional psychiatry en
dc.title Diet and depression: exploring the biological mechanisms of action en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard Clarke, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.clarke@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 6 months after publication by request of the publisher. en
dc.check.date 2021-05-03
dc.date.updated 2020-12-07T10:47:59Z
dc.description.version Accepted Version en
dc.internal.rssid 546692941
dc.internal.pmid 33144709
dc.contributor.funder Deakin University en
dc.contributor.funder Multiple Sclerosis Research Australia en
dc.contributor.funder Australian Rotary Health en
dc.contributor.funder National Health and Medical Research Council en
dc.contributor.funder Medical Research Council en
dc.contributor.funder Horizon 2020 en
dc.contributor.funder National Institute for Health Research en
dc.contributor.funder Irish Research Council en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung en
dc.contributor.funder Health Research Board en
dc.contributor.funder Institute for Scientific Information on Coffee, UK en
dc.contributor.funder Saks Kavanaugh Foundation, United States en
dc.contributor.funder University of Manchester en
dc.contributor.funder UK Research and Innovation en
dc.contributor.funder Australian Research Council en
dc.contributor.funder Waterloo Foundation en
dc.contributor.funder DNA Genotek en
dc.contributor.funder Trajan Scientific and Medical, Australia en
dc.contributor.funder Ministry of Science and Technology, Taiwan en
dc.contributor.funder National Health Research Institutes en
dc.contributor.funder Universidade de Macau en
dc.contributor.funder Ministry of Education en
dc.contributor.funder China Medical University, Taiwan en
dc.contributor.funder China Medical University Hospital en
dc.contributor.funder Nordic Naturals, United States en
dc.contributor.funder National Institute of Neurological Disorders and Stroke en
dc.contributor.funder Natural Sciences and Engineering Research Council of Canada en
dc.contributor.funder Ontario Brain Institute en
dc.contributor.funder Fonds Baillet Latour en
dc.contributor.funder Fonds De La Recherche Scientifique - FNRS en
dc.contributor.funder European Research Council en
dc.contributor.funder Centre Hospitalier Régional Universitaire de Montpellier en
dc.contributor.funder National Heart Foundation of Australia en
dc.contributor.funder Wilson Foundation en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Molecular Psychiatry en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.clarke@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary. en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::RIA/848228/EU/Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe/DISCOvERIE en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/797592/EU/Gut microbiota-Microglia Interactions in NeuroDevelopment/GutMIND en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEX en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP2::ERC/336452/EU/Gut microbiota, innate immunity and endocannabinoid system interactions link metabolic inflammation with the hallmarks of obesity and type 2 diabetes/ENIGMO en
dc.identifier.eissn 1476-5578


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