Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer

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dc.contributor.author Keane, Jonathan M.
dc.contributor.author Joyce, Susan A.
dc.contributor.author Gahan, Cormac G. M.
dc.contributor.author Hyland, Niall P.
dc.contributor.author Houston, Aileen M.
dc.date.accessioned 2021-01-05T12:10:32Z
dc.date.available 2021-01-05T12:10:32Z
dc.date.issued 2020-12-03
dc.identifier.citation Keane, J. M., Joyce, S. A., Gahan, C. G. M., Hyland, N. P. and Houston, A. (2020) 'Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer', in Kloc M. (ed.) Symbiosis: Cellular, Molecular, Medical and Evolutionary Aspects. Results and Problems in Cell Differentiation, Vol 69, Springer, Cham, pp. 581-603. doi: 10.1007/978-3-030-51849-3_22 en
dc.identifier.volume 69 en
dc.identifier.startpage 581 en
dc.identifier.endpage 603 en
dc.identifier.isbn 978-3-030-51848-6
dc.identifier.isbn 978-3-030-51849-3
dc.identifier.issn 0080-1844
dc.identifier.uri http://hdl.handle.net/10468/10856
dc.identifier.doi 10.1007/978-3-030-51849-3_22 en
dc.description.abstract The symbiosis between the gut microbiota and the host has been identified as an integral part of normal human physiology and physiological development. Research in germ-free or gnotobiotic animals has demonstrated the importance of this symbiosis in immune, vascular, hepatic, respiratory and metabolic systems. Disruption of the microbiota can also contribute to disease, and the microbiota has been implicated in numerous intestinal and extra-intestinal pathologies including colorectal cancer. Interactions between host and microbiota can occur either directly or indirectly, via microbial-derived metabolites. In this chapter, we focus on two major products of microbial metabolism, short-chain fatty acids and bile acids, and their role in colorectal cancer. Short-chain fatty acids are the products of microbial fermentation of complex carbohydrates and confer protection against cancer risk, while bile acids are compounds which are endogenous to the host, but undergo microbial modification in the large intestine leading to alterations in their bioactivity. Lastly, we discuss the ability of microbial modulation to mediate cancer risk and the potential to harness this ability as a prophylactic or therapeutic treatment in colorectal cancer. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Switzerland AG en
dc.rights © 2020, Springer Nature Switzerland AG. This is a post-peer-review, pre-copyedit version of an article published in Results and Problems in Cell Differentiation. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-51849-3_22 en
dc.subject Butyrate en
dc.subject Bile en
dc.subject Gut microbiota en
dc.subject Colon en
dc.subject Tumorigenesis en
dc.title Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Niall Hyland, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: n.hyland@ucc.ie en
dc.internal.authorcontactother Susan Joyce, Biochemistry & Cell Biology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: s.joyce@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-12-03
dc.date.updated 2021-01-05T11:45:11Z
dc.description.version Accepted Version en
dc.internal.rssid 550240778
dc.internal.rssid 550363091
dc.internal.pmid 33263888
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Results and Problems in Cell Differentiation en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress n.hyland@ucc.ie en
dc.internal.IRISemailaddress s.joyce@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en

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