Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome

Show simple item record

dc.contributor.author Wilmes, Lars
dc.contributor.author Collins, James M.
dc.contributor.author O'Riordan, Kenneth J.
dc.contributor.author O'Mahony, Siobhain M.
dc.contributor.author Cryan, John F.
dc.contributor.author Clarke, Gerard
dc.date.accessioned 2021-03-29T10:44:36Z
dc.date.available 2021-03-29T10:44:36Z
dc.date.issued 2021-02-13
dc.identifier.citation Wilmes, L., Collins, J. M., O'Riordan, K. J., O'Mahony, S. M., Cryan, J. F. and Clarke, G. (2021) 'Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome', Neurogastroenterology and Motility, 33(3), e14095 (13pp). doi: 10.1111/nmo.14095 en
dc.identifier.volume 33 en
dc.identifier.issued 3 en
dc.identifier.startpage 1 en
dc.identifier.endpage 13 en
dc.identifier.issn 1350-1925
dc.identifier.uri http://hdl.handle.net/10468/11166
dc.identifier.doi 10.1111/nmo.14095 en
dc.description.abstract Background: The gastrointestinal microbiota has emerged as a key regulator of gut-brain axis signalling with important implications for neurogastroenterology. There is continuous bidirectional communication between the gut and the brain facilitated by neuronal, endocrine, metabolic, and immune pathways. The microbiota influences these signalling pathways via several mechanisms. Studies have shown compositional and functional alterations in the gut microbiota in stress-related psychiatric disorders. Gut microbiota reconfigurations are also a feature of irritable bowel syndrome (IBS), a gut-brain axis disorder sharing high levels of psychiatric comorbidity including both anxiety and depression. It remains unclear how the gut microbiota alterations in IBS align with both core symptoms and these psychiatric comorbidities. Methods: In this review, we highlight common and disparate features of these microbial signatures as well as the associated gut-brain axis signalling pathways. Studies suggest that patients with either IBS, depression or anxiety, alone or comorbid, present with alterations in gut microbiota composition and harbor immune, endocrine, and serotonergic system alterations relevant to the common pathophysiology of these comorbid conditions. Key results: Research has illustrated the utility of fecal microbiota transplantation in animal models, expanding the evidence base for a potential causal role of disorder-specific gut microbiota compositions in symptom set expression. Moreover, an exciting study by Constante and colleagues in this issue highlights the possibility of counteracting this microbiota-associated aberrant behavioral phenotype with a probiotic yeast, Saccharomyces boulardii CNCM I-745. Conclusions and inferences: Such data highlights the potential for therapeutic targeting of the gut microbiota as a valuable strategy for the management of comorbid psychiatric symptoms in IBS. en
dc.description.sponsorship Science Foundation Ireland (SFI/12/RC/2273_P2) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. en
dc.rights © 2021, John Wiley & Sons, Inc. This is the peer reviewed version of the following item: Wilmes, L., Collins, J. M., O'Riordan, K. J., O'Mahony, S. M., Cryan, J. F. and Clarke, G. (2021) 'Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome', Neurogastroenterology and Motility, 33(3), e14095 (13pp), doi: 10.1111/nmo.14095, which has been published in final form at https://doi.org/10.1111/nmo.14095. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. en
dc.subject Anxiety en
dc.subject Comorbidity en
dc.subject Depression en
dc.subject IBS en
dc.subject Microbiota-gut-brain axis en
dc.title Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard Clarke, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.clarke@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2022-02-13
dc.date.updated 2021-03-05T11:14:07Z
dc.description.version Accepted Version en
dc.internal.rssid 557346772
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neurogastroenterology and Motility en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.clarke@ucc.ie en
dc.identifier.articleid e14095 en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::RIA/848228/EU/Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe/DISCOvERIE en
dc.identifier.eissn 1365-2982


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement