Genetic tools for investigating the biology of commensal lactobacilli

Show simple item record Fang, Fang O'Toole, Paul W. 2010-02-09T10:01:37Z 2010-02-09T10:01:37Z 2009 2009-01-01
dc.identifier.citation Fang F, O'Toole PW. (2009) Genetic tools for investigating the biology of commensal lactobacilli. Frontiers in Bioscience. 14 (1) 3111-3127. en
dc.identifier.volume 14 en
dc.identifier.issued 1 en
dc.identifier.startpage 3111 en
dc.identifier.endpage 3127 en
dc.identifier.issn 1093-9946
dc.identifier.doi 10.2741/3439
dc.description.abstract Lactobacilli belong to the genus Lactobacillus, the largest genus among the lactic acid bacteria (LAB). They are abundant in plant material and food resources, or they may inhabit niches in or on the bodies of humans and animals, as commensals. Lactobacilli of food origin are commercially important in the production of dairy products, fermented meats, vegetables, and sourdough, and many of their properties have been well studied. Commensal lactobacilli are good candidates for development as probiotics. In recent years, the general biology and host interaction mechanisms of commensal lactobacilli have attracted great interest. Although the metabolic pathways, predicted gene functions, and some phenotypic traits, of commensal lactobacilli can be inferred or deduced to an extent by the growing number of Lactobacillus genome sequencing project, various genetic tools are still required to confirm their phenotypic properties and biological traits. The current state of the art with respect to the available complement of genetic tools including genomic resources, and more traditional approaches to investigate the biology of commensal lactobacilli, will now be reviewed. en
dc.description.sponsorship Science Foundation Ireland (Centre for Science, Engineering and Technology) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers in Bioscience en
dc.rights © Frontiers in Bioscience en
dc.subject Lactobacillus en
dc.subject Probiotics en
dc.subject Genomics en
dc.subject Genetic Tools en
dc.subject Review en
dc.subject.lcsh Lactobacillus -- Genetics -- Research en
dc.subject.lcsh Lactic acid bacteria en
dc.subject.mesh Gene Expression Regulation en
dc.subject.mesh Gener Transfer Techniques en
dc.subject.mesh Genome, Bacterial en
dc.subject.mesh Lactobacillus/genetics en
dc.title Genetic tools for investigating the biology of commensal lactobacilli en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul W. O’Toole, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. E-mail: en
dc.internal.availability Full text available en
dc.description.version Accepted Version en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Bioscience en
dc.internal.IRISemailaddress en

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