Malnutrition & altered body composition in oncology: prevalence, aetiology, consequences & potential therapies

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dc.contributor.advisor Ryan, Aoife en
dc.contributor.advisor Power, Derek en Sullivan, Erin S. 2021-05-26T10:26:50Z 2021-05-26T10:26:50Z 2020-08-10 2020-08-10
dc.identifier.citation Sullivan, E. S. 2020. Malnutrition & altered body composition in oncology: prevalence, aetiology, consequences & potential therapies. PhD Thesis, University College Cork. en
dc.identifier.endpage 358 en
dc.description.abstract Malnutrition is common across all cancer sites and stages and its aetiology is multifactorial and complex. It is associated with poorer quality of life, increased morbidity and mortality and is often considered an inevitable consequence of cancer and its treatments. However, we lack efficacious treatments for cancer-related malnutrition. The aim of this thesis was to describe the epidemiology of malnutrition in cancer, examine the causes and consequences of the condition and explore potential treatment strategies. This thesis begins by estimating that across Ireland and the UK, 34% of cancer patients (128,892) are affected by clinically significant weight loss annually and there are 133,707 annual cases of cancer-related sarcopenia (35% patients affected). This thesis shows using computed tomography scans (the gold standard in body composition analysis) that abnormalities of body composition, including loss of fat without loss of muscle, are predictive of poor survival in advanced cancer. Furthermore, cachexia (a syndrome of disease-related appetite loss and wasting) was shown to be more prevalent in those with inflammation and poor performance status and the obesity paradox in colorectal cancer was confirmed (obesity is a risk factor for the disease, but is associated with improved survival). The nutritional experience of patients with cancer is described, namely that nutrition is a high priority for patients, who experience many dietary issues throughout their journey, but that information available to patients is lacking and referral to dietitians is very inconsistent. Finally, a placebo controlled trial of 2 novel dairy-derived, ghrelinergic peptides showed that one of the peptides investigated increased protein intake in healthy males by 23 g per day. Prompt identification of patients with cancer-related malnutrition must be optimised and development of an effective, evidence-based treatment strategy is of the utmost importance as it stands to improve longevity and quality of life for cancer survivors. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2020, Erin Stella Sullivan. en
dc.rights.uri en
dc.subject Malnutrition en
dc.subject Cancer en
dc.subject Cachexia en
dc.subject Sarcopenia en
dc.subject Nutrition en
dc.subject Dietetics en
dc.subject Appetite en
dc.subject Clinical trial en
dc.subject Epidemiology en
dc.subject Radiology en
dc.subject Oncology en
dc.title Malnutrition & altered body composition in oncology: prevalence, aetiology, consequences & potential therapies en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD - Doctor of Philosophy en
dc.internal.availability Full text not available en
dc.description.version Accepted Version en
dc.description.status Not peer reviewed en Food and Nutritional Sciences en
dc.check.chapterOfThesis Chapter 7 (page numbers 245-293) (document pages 304-352) Appendices XI-XV (page numbers 350-358) (document pages 416-427) en
dc.internal.conferring Summer 2021 en
dc.internal.ricu Cork Cancer Research Centre en
dc.internal.ricu HRB Clinical Research Facility at UCC en
dc.availability.bitstream embargoed 2024-05-30

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