Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction
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Accepted Version
Supplementary Data
Date
2018-04-27
Authors
Kumar, Vydula P.
Gupta, Manoj K.
Horgan, Conor
O'Sullivan, Timothy P.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd.
Published Version
Abstract
The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor.
Description
Keywords
Alkyne zipper reaction , Diffusible Signal Factor , Partial hydrogenation , Therapy
Citation
Kumar, V. P., Gupta, M. K., Horgan, C. and O'Sullivan, T. P. (2018) 'Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction', Tetrahedron Letters, 59(22), pp. 2193-2195. doi: 10.1016/j.tetlet.2018.04.071