Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

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Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

Kumar, Vydula P.; Gupta, Manoj K.; Horgan, Conor; O'Sullivan, Timothy P.
Date: 2018-04-27
Copyright: © 2018, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
Copyright information: https://creativecommons.org/licenses/by-nc-nd/4.0/
Citation: Kumar, V. P., Gupta, M. K., Horgan, C. and O'Sullivan, T. P. (2018) 'Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction', Tetrahedron Letters, 59(22), pp. 2193-2195. doi: 10.1016/j.tetlet.2018.04.071
Published Version: 10.1016/j.tetlet.2018.04.071

Abstract:

The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor.

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© 2018, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2018, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
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