Citation:Kumar, V. P., Gupta, M. K., Horgan, C. and O'Sullivan, T. P. (2018) 'Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction', Tetrahedron Letters, 59(22), pp. 2193-2195. doi: 10.1016/j.tetlet.2018.04.071
The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor.
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