Genome-scale analyses of health-promoting bacteria: probiogenomics
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Accepted Version
Date
2009-01
Authors
Ventura, Marco
O'Flaherty, Sarah
Claesson, Marcus J.
Turroni, Francesca
Klaenhammer, Todd R.
van Sinderen, Douwe
O'Toole, Paul W.
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Published Version
Abstract
The human body is colonized by an enormous population of bacteria (microbiota) that provides the host with coding capacity and metabolic activities. Among the human gut microbiota are health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. Recent genomics-based studies (probiogenomics) are starting to provide insights into how probiotic bacteria sense and adapt to the gastrointestinal tract environment. In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.
Description
Keywords
Genomics , Functional genomics , Microbiota , Intestinal tract , Probiotic bacteria
Citation
Ventura M., O'Flaherty S., Claesson M. J., Turroni F., Klaenhammer T.R., van Sinderen D., O'Toole P.W. 2009. Genome-scale analyses of health-promoting bacteria: probiogenomics. Nature Reviews Microbiology 7, pp61-71 doi:10.1038/nrmicro2047