Investigation of the function of the LNX family of E3 ubiquitin ligases in the nervous system

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dc.contributor.advisor Young, Paul en Saha, Orthis 2013-07-18T12:01:41Z 2013 2013
dc.identifier.citation Saha, O. 2013. Investigation of the function of the LNX family of E3 ubiquitin ligases in the nervous system. PhD Thesis, University College Cork. en
dc.description.abstract The Lnx1 (Ligand of Numb protein X 1) and Lnx2 genes belong to a family of PDZ domain-containing RING finger domain E3 ubiquitin ligases. mRNA expression for both genes have been reported in early murine central nervous system. However, there have been limited reports with regards to the expression patterns for both the proteins in vivo. Hence, we have attempted to characterize the significance of these proteins in the context of morphology and physiology of the central nervous system. Through our studies, we have attempted to examine closely the expression of these two genes in the murine central nervous system. We have also looked at novel interacting ligands for both proteins. Interacting partners have been examined with particular relevance to possible roles of their interactions with LNX1 and LNX2 in the functioning of the nervous system. Moreover, we have performed loss-of-function studies by way of creation and characterization of knockout mice. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2013, Orthis Saha en
dc.rights.uri en
dc.subject LNX1 en
dc.subject LNX2 en
dc.subject Murine central nervous system en
dc.subject mRNA expression en
dc.subject.lcsh Mice--Physiology en
dc.subject.lcsh Gene expression en
dc.subject.lcsh Central nervous system en
dc.title Investigation of the function of the LNX family of E3 ubiquitin ligases in the nervous system en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text not available en Indefinite en 10000-01-01
dc.description.version Accepted Version
dc.description.status Not peer reviewed en Biochemistry en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Yes en
dc.thesis.opt-out true *
dc.check.entireThesis Entire Thesis Restricted
dc.check.embargoformat Both hard copy thesis and e-thesis en

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