Restriction lift date: 2022-09-30
The microbiome and cancer
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Full Text E-thesis
Date
2021-06-04
Authors
Barrett, Maurice P. J.
Journal Title
Journal ISSN
Volume Title
Publisher
University College Cork
Published Version
Abstract
Cancers arise through the process of somatic evolution fuelled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumour microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the substrate for somatic mutations. An understanding of microbiota-driven mutational mechanism would contribute to a more complete understanding of the origins of the cancer genome. Here we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures.
Description
Keywords
Microbiome , Microbiota , Cancer
Citation
Barrett, M. P. J. 2021. The microbiome and cancer. PhD Thesis, University College Cork.