Life in the Fas lane: differential outcomes of Fas signalling

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dc.contributor.author Brint, Elizabeth K.
dc.contributor.author O'Callaghan, Grace
dc.contributor.author Houston, Aileen M.
dc.date.accessioned 2013-07-31T09:50:16Z
dc.date.available 2014-11-01T05:00:05Z
dc.date.issued 2013-11-01
dc.identifier.citation BRINT, E., O’CALLAGHAN, G. & HOUSTON, A. 2013. Life in the Fas lane: differential outcomes of Fas signaling. Cellular and Molecular Life Sciences, 70, 4085-4099. doi: 10.1007/s00018-013-1327-z en
dc.identifier.issn 1420-9071
dc.identifier.uri http://hdl.handle.net/10468/1205
dc.identifier.doi 10.1007/s00018-013-1327-z
dc.description.abstract Fas, also known as CD95 or APO-1, is a member of the tumor necrosis factor/nerve growth factor superfamily. Although best characterized in terms of its apoptotic function, recent studies have identified several other cellular responses emanating from Fas. These responses include migration, invasion, inflammation, and proliferation. In this review, we focus on the diverse cellular outcomes of Fas signaling and the molecular switches identified to date that regulate its pro- and anti-apoptotic functions. Such switches occur at different levels of signal transduction, ranging from the receptor through to cross-talk with other signaling pathways. Factors identified to date including other extracellular signals, proteins recruited to the death-inducing signaling complex, and the availability of different intracellular components of signal transduction pathways. The success of therapeutically targeting Fas will require a better understanding of these pathways, as well as the regulatory mechanisms that determine cellular outcome following receptor activation. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer en
dc.relation.uri http://link.springer.com/article/10.1007%2Fs00018-013-1327-z/fulltext.html
dc.rights © Springer Basel 2013. The final publication is available at link.springer.com. en
dc.subject Fas/CD95 en
dc.subject DISC en
dc.subject Apoptosis en
dc.subject NF-κB en
dc.subject Non-apoptotic en
dc.subject Regulation en
dc.title Life in the Fas lane: differential outcomes of Fas signalling en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://research.ucc.ie/profiles/C012/ahouston en
dc.internal.authorcontactother Aileen Houston, Medicine Department , University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.houston@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to the full text restricted for 1 year by request of the publisher en
dc.date.updated 2013-07-03T08:31:52Z
dc.description.version Accepted Version en
dc.internal.rssid 212807298
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Cellular and Molecular Life Sciences : CMLS en
dc.internal.copyrightchecked No en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.houston@ucc.ie en


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