Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles

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dc.contributor.author Gao, Yuan
dc.contributor.author Liang, Kunneng
dc.contributor.author Weir, Michael D.
dc.contributor.author Gao, Jianghong
dc.contributor.author Imazato, Satoshi
dc.contributor.author Tay, Franklin R.
dc.contributor.author Lynch, Christopher D.
dc.contributor.author Oates, Thomas W.
dc.contributor.author Li, Jiyao
dc.contributor.author Xu, Hockin H.K.
dc.date.accessioned 2021-11-18T11:45:05Z
dc.date.available 2021-11-18T11:45:05Z
dc.date.issued 2019-12-11
dc.identifier.citation Semple, C. J., Rutherford, H., Killough, S., Moore, C. and McKenna, G. (2019) 'Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles', Journal of Dentistry, 92, 103262 (8pp). doi:10.1016/j.jdent.2019.103262 en
dc.identifier.volume 92 en
dc.identifier.startpage 1 en
dc.identifier.endpage 8 en
dc.identifier.issn 0300-5712
dc.identifier.uri http://hdl.handle.net/10468/12227
dc.identifier.doi 10.1016/j.jdent.2019.103262 en
dc.description.abstract Objectives:The objective of this study was to investigate enamel remineralization using salivary statherin pro-tein-inspired poly(amidoamine) dendrimer (SN15-PAMAM) and adhesive containing nanoparticles of amor-phous calcium phosphate (NACP) in a cyclic artificial saliva/demineralizing solution for thefirst time.Methods:The enamel shear bond strengths of NACP adhesives were measured compared to commercial adhesive(Scotchbond Multi-Purpose, 3 M). Adhesive disks containing NACP were tested for calcium (Ca) and phosphorus(P) ions release. Four groups were tested: (1) enamel control, (2) enamel with NACP, (3) enamel with SN15-PAMAM, and (4) enamel with SN15-PAMAM + NACP. The specimens were treated with cyclic artificial saliva/demineralizing solution for 28 days. The remineralized enamel specimens were examined by surface and cross-sectional hardness test.Results:NACP adhesive yielded a similar shear bond strength to commercial control (Scotchbond Multi-Purpose,3 M). NACP adhesive released high levels of Ca and P ions. At 28 days, the enamel hardness of SN15-PAMAM +NACP group was 2.89 ± 0.13 GPa, significantly higher than that of control group (1.46 ± 0.10 GPa) (p< 0.05).SN15-PAMAM + NACP increased the enamel cross-sectional hardness at 28 days; at 25μm, enamel cross-sectional hardness was 90 % higher than that of control group (p< 0.05).Significance:The novel SN15-PAMAM + NACP adhesive method could achieve 90 % higher enamel reminer-alization of the artificial caries than the control under acid challenge for thefirst time. This method is promisingfor use after tooth cavity preparation, or as a coating on enamel with white spot lesions (WSLs) for prevention, toreduce secondary caries, prevent caries procession and protect tooth structures. en
dc.description.sponsorship National Natural Science Foundation of China (81670977 (L.J.Y.) and 81800965 (L.K.N.)); Sichuan Province Science and Technology Support Program (Grant No. 2017SZ0030); Fundamental Research Funds for Central Universities of the Central South University (2018SCU12016 (L.K.N.)); Research Fund of West China Hospital (<GN4>WCHS-201705</GN4> (L.K.N.)); China Postdoctoral Foundation (2018M643507 (L.K.N.)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2019 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Enamel remineralization en
dc.subject Statherin protein poly(amidoamine) dendrimer en
dc.subject Adhesive en
dc.subject pH cycling en
dc.subject Nano-calcium phosphate en
dc.subject Enamel hardness en
dc.title Enamel remineralization via poly(amido amine) and adhesive resin containing calcium phosphate nanoparticles en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Christopher Lynch, Restorative Dentistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: chris.lynch@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Accepted Version en
dc.contributor.funder National Natural Science Foundation of China en
dc.contributor.funder Sichuan Province Science and Technology Support Program en
dc.contributor.funder Fundamental Research Funds for Central Universities of the Central South University en
dc.contributor.funder Research Fund of West China Hospital en
dc.contributor.funder China Postdoctoral Foundation en
dc.contributor.funder University of Maryland, Baltimore County en
dc.contributor.funder School of Dentistry, University of Maryland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Dentistry en
dc.internal.IRISemailaddress chris.lynch@ucc.ie en
dc.identifier.articleid 103262 en


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© 2019 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2019 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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