• The microbiota and colon cancer risk: cause or consequence? 

  Keane, Jonathan (University College Cork, 2019)

  Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut ...
• Insights into the human gut microbial eukaryome 

  Huseyin, Chloe E. (University College Cork, 2019)

  The microbial inhabitants of the human gut have long been the subject of considerable scrutiny and scientific research effort (Anderson 1917; Savage 1977) and as their importance continues to be realised, not just in terms ...
• Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption 

  Enright, Elaine F. (University College Cork, 2019)

  In recent years, it has been elucidated that, in addition to host genetics, the gut microbiome must be considered as a source of pharmacokinetic variability. As newly emerging drug candidates trend toward low solubility ...
• Investigation of the mechanisms underpinning interaction of Bifidobacterium breve with the host 

  Hickey, Ana Claire (University College Cork, 2019)

  Bifidobacteria are one of the first bacterial genera to colonise the gastrointestinal tract of human infants, are found in breast milk, are reported to influence immunity and to affect susceptibility to infectious and ...
• Effects of psychotropic drugs on the microbiota-gut-liver-brain axis 

  Cussotto, Sofia (University College Cork, 2019)

  There is a growing recognition of the involvement of the gut microbiota in drug metabolism and vice versa the impact of drug intake on the microbiome. In this thesis, we focus our attention on psychotropic medications (from ...

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