Pulmonary mucosa-associated lymphoid tissue lymphoma- A single center review of the diagnostic approach
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Date
2020-06-12
Authors
Farrell, A. M.
Farrell, S. A.
Kennedy, Marcus P.
Henry, M. T.
Journal Title
Journal ISSN
Volume Title
Publisher
Springer London Ltd.
Published Version
Abstract
Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease, and diagnosis is difficult, often requiring multiple attempts at tissue sampling. The aim of this review was to evaluate the diagnostic pathway. A retrospective review was performed of patients diagnosed with pulmonary MALT lymphoma in a tertiary referral lung cancer center over 9 years. Ten patients were identified, and each diagnostic and treatment approach was analysed. 30% were diagnosed via transbronchial biopsy, two with the assistance of radial probe ultrasound guidance and one with transbronchial lung cryobiopsy of a predetermined CT-guided targeted segment. 70% were diagnosed following surgical biopsy. 40% had localized disease. The diagnosis was not successfully achieved until a large-sized tissue specimen was obtained. The implementation of novel bronchoscopy techniques can assist in reducing the number of invasive surgical procedures required to obtain a diagnosis. All cases should be discussed in a multidisciplinary setting prior to diagnostic attempts.
Description
Keywords
Pulmonary mucosa-associated lymphoid tissue , MALT , Lymphoma , Lung cancer , Bronchoalveolar lavage , Cryobiopsy , Transbronchial biopsy
Citation
Farrell, A. M., Farrell, S. A., Kennedy, M. P. and Henry, M. T. (2020) 'Pulmonary mucosa-associated lymphoid tissue lymphoma- A single center review of the diagnostic approach', Clinical Oncology and Research, 3(6), pp. 1-6. doi: 10.31487/j.COR.2020.06.06