Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects
Loading...
Files
Accepted Version
Date
2022-02-17
Authors
Leigh, Sarah-Jane
Lynch, Caoimhe M. K.
Healey Bird, Brian R.
Griffin, Brendan T.
Cryan, John F.
Clarke, Gerard
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Published Version
Abstract
Introduction: The gut microbiota is involved in host physiology and health. Reciprocal microbiota-drug interactions are increasingly recognized as underlying some individual differences in therapy response and adverse events. Cancer pharmacotherapies are characterized by a high degree of interpatient variability in efficacy and side effect profile and recently, the microbiota has emerged as a factor that may underlie these differences. Areas covered: The effects of cancer pharmacotherapy on microbiota composition and function are reviewed with consideration of the relationship between baseline microbiota composition, microbiota modification, antibiotics exposure and cancer therapy efficacy. We assess the evidence implicating the microbiota in cancer therapy-related adverse events including impaired gut function, cognition and pain perception. Finally, potential mechanisms underlying microbiota-cancer drug interactions are described, including direct microbial metabolism, and microbial modulation of liver metabolism and immune function. This review focused on preclinical and clinical studies conducted in the last 5 years. Expert opinion: Preclinical and clinical research supports a role for baseline microbiota in cancer therapy efficacy, with emerging evidence that the microbiota modification may assist in side effect management. Future efforts should focus on exploiting this knowledge towards the development of microbiota-targeted therapies. Finally, a focus on specific drug-microbiota-cancer interactions is warranted.
Description
Keywords
Cancer therapy , Chemotherapy , Gut microbiome , Gut-brain axis , Immunotherapy , Pharmacomicrobiomics , Tyrosine kinase inhibitors
Citation
Leigh, S.-J., Lynch, C. M. K., Healey Bird, B. R., Griffin, B. T., Cryan, J. F. and Clarke, G. (2022) 'Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects', Expert Opinion on Drug Metabolism and Toxicology. doi: 10.1080/17425255.2022.2043849
Link to publisher’s version
Copyright
© 2022, Taylor & Francis Group, LLC. This is an Accepted Manuscript of an item published by Taylor & Francis in Computer Methods in Expert Opinion on Drug Metabolism and Toxicology on 17 February 2022, available online: https://doi.org/10.1080/17425255.2022.2043849