Effect of plasma rich in growth factors on quality of life following mandibular third molar removal: a double-blind randomized controlled trial

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dc.contributor.author O'Sullivan, Laura
dc.contributor.author Gallagher, Catherine
dc.contributor.author Ní­ Ríordáin, Richeal
dc.date.accessioned 2022-03-02T15:52:40Z
dc.date.available 2022-03-02T15:52:40Z
dc.date.issued 2022-02-17
dc.identifier.citation O'Sullivan, L., Gallagher, C. and Ní Rí­ordáin, R. (2022) 'Effect of plasma rich in growth factors on quality of life following mandibular third molar removal: a double-blind randomized controlled trial', International Journal of Oral and Maxillofacial Surgery. doi: 10.1016/j.ijom.2022.02.003 en
dc.identifier.issn 0901-5027
dc.identifier.uri http://hdl.handle.net/10468/12693
dc.identifier.doi 10.1016/j.ijom.2022.02.003 en
dc.description.abstract The objective of this study was to investigate the effect of plasma rich in growth factors (PRGF) on patient- and clinician-reported outcomes following mandibular third molar removal. Seventy-four patients requiring surgical removal of a unilateral impacted mandibular third molar under local anaesthesia were recruited into the study. PRGF was prepared for all patients irrespective of study arm allocation. Reviews were conducted 3 days (T1) and 7 days (T2) postoperatively. Primary outcome measures were pain (numerical rating scale, NRS), OHIP-14 (Oral Health Impact Profile-14), and postoperative symptom severity scale (PoSSe) data. Secondary outcome measures including mouth opening, dry socket, socket healing, and analgesic consumption were also explored. The statistical analysis was performed using analysis of covariance and the χ2 test. NRS pain scores were higher in the PRGF group at T1, demonstrating borderline significance (mean difference 1.0; P = 0.06), with no difference at T2. PoSSe scores did not differ between the groups, with the exception of the ‘interference with daily activities’ subscale at T1, where PRGF group patients scored 1.2 units higher (P = 0.02). OHIP-14 scores demonstrated a 25% increased likelihood of PRGF patients reporting discomfort on eating at T1 (P = 0.02), with no statistical significance at T2. Secondary outcomes did not differ between the groups. No difference in clinical or quality of life outcomes was observed for patients receiving adjunctive PRGF in third molar sockets. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Inc. en
dc.rights © 2022, International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Third molar en
dc.subject Wisdom teeth en
dc.subject Platelet-rich plasma en
dc.subject Quality of life en
dc.subject Platelet-rich fibrin en
dc.subject Plasma en
dc.subject Randomized controlled trial en
dc.title Effect of plasma rich in growth factors on quality of life following mandibular third molar removal: a double-blind randomized controlled trial en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Laura O'Sullivan, Dental Surgery, University College Cork, Cork, Ireland. +353-21-490-3000 Email: laura.osullivan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2023-02-17
dc.date.updated 2022-03-02T15:39:49Z
dc.description.version Accepted Version en
dc.internal.rssid 602947817
dc.description.status Peer reviewed en
dc.identifier.journaltitle International Journal of Oral and Maxillofacial Surgery en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress laura.osullivan@ucc.ie en
dc.internal.bibliocheck In press. Add vol / issue / page numbers. Amend citation and copyright statement as necessary. en
dc.identifier.eissn 1399-0020


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© 2022, International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2022, International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
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