Association between social deprivation and incidence of first seizures and epilepsy: A prospective population-based cohort

Show simple item record

dc.contributor.author Maloney, Eimer M.
dc.contributor.author Corcoran, Paul
dc.contributor.author Costello, Daniel J.
dc.contributor.author O'Reilly, Éilis J.
dc.date.accessioned 2022-06-27T13:43:33Z
dc.date.available 2022-06-27T13:43:33Z
dc.date.issued 2022-05-25
dc.identifier.citation Maloney, E. M., Corcoran, P., Costello, D. J. and O'Reilly, É J. (2022) 'Association between social deprivation and incidence of first seizures and epilepsy: A prospective population-based cohort', Epilepsia. doi: 10.1111/epi.17313 en
dc.identifier.issn 0013-9580
dc.identifier.uri http://hdl.handle.net/10468/13317
dc.identifier.doi 10.1111/epi.17313 en
dc.description.abstract Objective: Epidemiologic studies have investigated whether social deprivation is associated with a higher incidence of epilepsy, and results are conflicting, especially in children. The mechanisms underlying a potential association are unclear. This study examines whether there is an association between social deprivation and the incidence of first seizures (unprovoked and provoked) and new diagnosis of epilepsy by comparing incidence across an area-level measure of deprivation in a population-based cohort. Methods: Multiple methods of case identification followed by individual case validation and classification were carried out in a defined geographical area (population 542 868) to identify all incident cases of first provoked and first unprovoked seizures and new diagnosis of epilepsy presenting during the calendar year 2017. An area-level relative deprivation index, based on 10 indicators from census data, was assigned to each patient according to registered address and categorized into quintiles from most to least deprived. Results: The annual incidence of first unprovoked seizures (n = 372), first provoked seizures (n = 189), and new diagnosis of epilepsy (n = 336) was highest in the most deprived areas compared to the least deprived areas (incidence ratios of 1.79 [95% confidence interval (CI) = 1.26–2.52], 1.55 [95% CI = 1.04–2.32], and 1.83 [95% CI = 1.28–2.62], respectively). This finding was evident in both adults and children and in those with structural and unknown etiologies of epilepsy. Significance: The incidence of first seizures and new diagnosis of epilepsy is associated with more social deprivation. The reason for this higher incidence is likely multifactorial. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. en
dc.rights © 2022, the Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Epilepsy en
dc.subject Incidence en
dc.subject Seizures en
dc.subject Social deprivation en
dc.title Association between social deprivation and incidence of first seizures and epilepsy: A prospective population-based cohort en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Eimer Maloney, Medicine, University College Cork, Cork, Ireland. T: +353-21- 490-3000 en
dc.internal.availability Full text available en
dc.date.updated 2022-06-27T13:30:38Z
dc.description.version Published Version en
dc.internal.rssid 617572811
dc.internal.pmid 35611982
dc.description.status Peer reviewed en
dc.identifier.journaltitle Epilepsia en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.bibliocheck In press. Add vol / issue / page numbers. Amend citation and copyright statement as necessary. en
dc.identifier.eissn 1528-1167


Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2022, the Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. Except where otherwise noted, this item's license is described as © 2022, the Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement