Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

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dc.contributor.author Pazukhina, Ekaterina
dc.contributor.author Andreeva, Margarita
dc.contributor.author Spiridonova, Ekaterina
dc.contributor.author Bobkova, Polina
dc.contributor.author Shikhaleva, Anastasia
dc.contributor.author El-Taravi, Yasmin
dc.contributor.author Rumyantsev, Mikhail
dc.contributor.author Gamirova, Aysylu
dc.contributor.author Bairashevskaia, Anastasiia
dc.contributor.author Petrova, Polina
dc.contributor.author Baimukhambetova, Dina
dc.contributor.author Pikuza, Maria
dc.contributor.author Abdeeva, Elina
dc.contributor.author Filippova, Yulia
dc.contributor.author Deunezhewa, Salima
dc.contributor.author Nekliudov, Nikita
dc.contributor.author Bugaeva, Polina
dc.contributor.author Bulanov, Nikolay
dc.contributor.author Avdeev, Sergey
dc.contributor.author Kapustina, Valentina
dc.contributor.author Guekht, Alla
dc.contributor.author DunnGalvin, Audrey
dc.contributor.author Comberiati, Pasquale
dc.contributor.author Peroni, Diego G.
dc.contributor.author Apfelbacher, Christian
dc.contributor.author Genuneit, Jon
dc.contributor.author Reyes, Luis Felipe
dc.contributor.author Brackel, Caroline L. H.
dc.contributor.author Fomin, Victor
dc.contributor.author Svistunov, Andrey A.
dc.contributor.author Timashev, Peter
dc.contributor.author Mazankova, Lyudmila
dc.contributor.author Miroshina, Alexandra
dc.contributor.author Samitova, Elmira
dc.contributor.author Borzakova, Svetlana
dc.contributor.author Bondarenko, Elena
dc.contributor.author Korsunskiy, Anatoliy A.
dc.contributor.author Carson, Gail
dc.contributor.author Sigfrid, Louise
dc.contributor.author Scott, Janet T.
dc.contributor.author Greenhawt, Matthew
dc.contributor.author Buonsenso, Danilo
dc.contributor.author Semple, Malcolm G.
dc.contributor.author Warner, John O.
dc.contributor.author Olliaro, Piero
dc.contributor.author Needham, Dale M.
dc.contributor.author Glybochko, Petr
dc.contributor.author Butnaru, Denis
dc.contributor.author Osmanov, Ismail M.
dc.contributor.author Munblit, Daniel
dc.contributor.author Sechenov StopCOVID Research Team
dc.date.accessioned 2022-09-22T14:42:14Z
dc.date.available 2022-09-22T14:42:14Z
dc.date.issued 2022-07-06
dc.identifier.citation Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., Rumyantsev, M., Gamirova, A., Bairashevskaia, A., Petrova, P., Baimukhambetova, D., Pikuza, M., Abdeeva, E., Filippova, Y., Deunezhewa, S.,Nekliudov, N., Bugaeva, P., Bulanov, N., Avdeev, S., Kapustina, V., Guekht, A., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Reyes, L. F., Brackel, C. L. H., Fomin, V., Svistunov, A. A., Timashev, P., Mazankova, L., Miroshina, A., Samitova, E., Borzakova, S., Bondarenko, E., Korsunskiy, A. A., Carson, G., Sigfrid, L., Scott, J. T., Greenhawt, M., Buonsenso, D., Semple, M. G., Warner, J. O., Olliaro, P., Needham, D. M., Glybochko, P., Butnaru, D., Osmanov, I. M., Munblit, D. and the Sechenov StopCOVID Research Team (2022) 'Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)', BMC Medicine, 20(1), 244 (12pp). doi: 10.1186/s12916-022-02448-4 en
dc.identifier.volume 20 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.uri http://hdl.handle.net/10468/13647
dc.identifier.doi 10.1186/s12916-022-02448-4 en
dc.description.abstract Background: Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods: Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results: One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions: Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BioMed Central Ltd en
dc.rights © 2022, the Authors. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Adults en
dc.subject Children en
dc.subject COVID-19 en
dc.subject COVID-19 sequelae en
dc.subject Long COVID en
dc.subject Post-acute sequelae of SARS-CoV-2 en
dc.subject infection en
dc.subject PASC en
dc.subject Post-COVID-19 condition en
dc.subject Prevalence en
dc.subject Risk factor en
dc.title Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Audrey Dunn Galvin, Paediatrics & Child Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.dunngalvin@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2022-09-22T14:15:35Z
dc.description.version Published Version en
dc.internal.rssid 628277209
dc.internal.pmid 35794549
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Medicine en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.dunngalvin@ucc.ie en
dc.identifier.articleid 244 en
dc.identifier.eissn 1741-7015


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© 2022, the Authors. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Except where otherwise noted, this item's license is described as © 2022, the Authors. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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