High contrast breast cancer biomarker imaging using upconverting nanoparticles
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Date
2022-04
Authors
Sekar, Sanathana K. V.
Ma, Hui
Komolibus, Katarzyna
Dumlupinar, Gokhan
Krawczyk, Krzysztof
Mickert, Matthias
Andersson-Engels, Stefan
Journal Title
Journal ISSN
Volume Title
Publisher
Optica Publishing Group
Published Version
Abstract
Breast cancer is a leading cause of death in women and has scope for improvement in treatment stratification. We report the use of high contrast UCNP staining to distinguish different levels of HER2 expression in HER2 analyte control and HER2-positive breast cancer tissue biopsies. A contrast of 40 was found as compared to the negative control and 25 as compared to conventional DAB staining.
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Keywords
Breast cancer , High contrast UCNP staining , Breast cancer tissue biopsies , HER2 expression , Emission , Fourier transforms , Image processing , Microscopy , Nanoparticles , Tissue
Citation
Sekar, S.K.V., Ma, H., Komolibus, K., Dumlupinar, G., Krawczyk, K., Mickert, M. and Andersson-Engels, S. (2022) ‘High contrast breast cancer biomarker imaging using upconverting nanoparticles’, in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), 24-27 April. https://doi.org/10.1364/TRANSLATIONAL.2022.JM1A.4
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© 2022 The Author(s). Published by Optical Publishing Group